NDLI: Presynaptic local signaling by a canonical wingless pathway regulates development of the Drosophila neuromuscular junction.

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Presynaptic local signaling by a canonical wingless pathway regulates development of the Drosophila neuromuscular junction.

Content Provider	Semantic Scholar
Author	Miech, Claudia Pauer, H. J. Schwarz, Thomas L.
Copyright Year	2008
Abstract	Wnt/wingless signaling contributes to the development of neuronal synapses, including the Drosophila neuromuscular junction. Loss of wg (wingless) function alters the number and structure of boutons at this model synapse. Examining Wnt/wingless signaling mechanisms, we find that a distinct pathway operates presynaptically in the motoneuron and can account for many of the effects of wingless at this synapse. This pathway includes the canonical elements arrow/LRP (low-density lipoprotein receptor-related protein), dishevelled, and the glycogen synthase kinase shaggy (GSK3) and regulates the formation of microtubule loops within synaptic boutons as well as the number of synaptic boutons. This pathway, however, appears to be independent of beta-catenin signaling and the transcriptional regulation that is most frequently downstream of these components. Instead, inhibition of shaggy is likely to act locally. This pathway thus provides a parallel mechanism to the postsynaptic activation of frizzled receptors and indicates that synaptic development results from the bidirectional influence of wingless on both presynaptic and postsynaptic structures via distinct intracellular pathways.
Starting Page	22633
Ending Page	22637
Page Count	5
File Format	PDF HTM / HTML
Alternate Webpage(s)	http://www.jneurosci.org/content/jneuro/28/43/10875.full.pdf
PubMed reference number	18945895v1
Alternate Webpage(s)	https://doi.org/10.1523/JNEUROSCI.0164-08.2008
DOI	10.1523/jneurosci.0164-08.2008
Journal	The Journal of neuroscience : the official journal of the Society for Neuroscience
Volume Number	28
Issue Number	43
Language	English
Access Restriction	Open
Subject Keyword	Catenins Frizzled Receptors Glycogen (Starch) Synthase Glycogen Synthase Kinase 3 Glycogen Synthase Kinases LDLR protein, human Lipoprotein Receptor Lipoproteins Microtubules Motor Neurons Neuromuscular Junction Presynaptic Terminals Synapses Transcriptional Regulation beta catenin
Content Type	Text
Resource Type	Article

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