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Alcohol and long-term prognosis after a first acute myocardial infarction: the SHEEP study.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Janszky, Imre Ljung, Rickard Ahnve, Staffan Hallqvist, Johan Bennet, Anna Michaela Mukamal, Kenneth Jay |
| Copyright Year | 2008 |
| Abstract | CONTEXT Few studies have investigated the relation between alcohol consumption, former drinking, and prognosis after an acute myocardial infarction (AMI), particularly for non-fatal outcomes. OBJECTIVE To investigate the prognostic importance of drinking habits among patients surviving a first AMI. DESIGN, SETTINGS, AND PATIENTS A total of 1346 consecutive patients between 45-70 years with a first non-fatal AMI underwent a standardized clinical examination and were followed for over 8 years. MAIN OUTCOME MEASURES Total and cardiac mortality and hospitalization for non-fatal cardiovascular disease in relation to individual alcoholic beverage consumption at the time of AMI and 5 years before inclusion, assessed by a standardized questionnaire administered during hospitalization. RESULTS We recorded 267 deaths, and 145 deaths from cardiac causes, during the follow-up period. After adjustment for several potential confounders, hazard ratios for total and cardiac mortality were 0.77 (0.51-1.15) and 0.61 (0.36-1.02) for those drinking >0-<5 g per day, 0.77 (0.50-1.18) and 0.62 (0.36-1.07) for those drinking 5-20 g per day, and 0.89 (0.56-1.40) and 0.69 (0.38-1.25) for those drinking over 20 g per day. Risk of hospitalization for recurrent non-fatal AMI, stroke, or heart failure generally showed a similar pattern to that of total and cardiac mortality. Recent quitters at the time of AMI had a hazard ratio of 4.55 (2.03-10.20) for total mortality. Measures of insulin sensitivity appeared to be the strongest mediators of this association. CONCLUSIONS Moderate alcohol drinking might have beneficial effects on several aspects of long-term prognosis after an AMI. Our findings also highlight that former drinkers should be examined separately from long-term abstainers. The potential mechanisms that underlie this association still need to be elucidated. |
| Starting Page | 45 |
| Ending Page | 53 |
| Page Count | 9 |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | https://oup.silverchair-cdn.com/oup/backfile/Content_public/Journal/eurheartj/29/1/10.1093_eurheartj_ehm509/2/ehm509.pdf?Expires=1492456512&Key-Pair-Id=APKAIUCZBIA4LVPAVW3Q&Signature=cmydYxH2QOLwbKj~9X2Ey36dNwkrhVvpIV3MUHVAn8474xgcMr5Yg~dBjO3aCAKUFovFVFQVF~vonWAvaRD5fW1RxbyzkW3-h1EcqGoakp1N~1fofxCJ0T0uuMimr3x2Txl2HPefPO5JR-OQiMQSREoZqthc1pdBY5T1R1L8bYVKDqqkc3P7tfgvZ9az9vgw68d0-wIYH33W0BEuoTAhGkrrjnLC6vxtR~k06o88X8ZPF23H3hHT0E36PBuMQLHl1bvhbEECp3gx5qmUhGfVcBG4AEW-EgmCmu1C7qFo6CosCsanfff6yn-KoP8BJ95C7JbdOMmr5~YXm3CbbnjMrg__ |
| Alternate Webpage(s) | https://watermark.silverchair.com/ehm509.pdf?token=AQECAHi208BE49Ooan9kkhW_Ercy7Dm3ZL_9Cf3qfKAc485ysgAAAbIwggGuBgkqhkiG9w0BBwagggGfMIIBmwIBADCCAZQGCSqGSIb3DQEHATAeBglghkgBZQMEAS4wEQQMm4ve-TymXfIHu3xIAgEQgIIBZZf1m7wN3XTDVekAeeiEkECyN-73P-cUmx6JRm-tMiEWWFnsW6venoYMmErz_L5UKXOZeX1EjbCAVFF0Yai4K0TtQawsOhMwU1VNuSnRa8rdz6_-QVE-EtcVYDJNCvgyfNU_8RGjIMXNdFXg7asLLaD6NqkbLp6m7wKTXsJzUOSW8vHWC16U7hvCGL9ztVimsDLYL51QARR5cO14PCK-0QMZgfZAjEXi1-kmrqIuysURL5S5yDVSmFQkafOvYtU1ZA_yszE_MgqIbEoU4qMs9gqH0mGmO6O4iNbiCwxDApWdnyPEyjf9gPunD_DDdaCoXVtFQ6-A8sggyRVBhbqWiL3JCmw9PYlzuhQ8EoFw9EUCRB9CrP6OC5v7NSTY51KSR9w_4tLefGvvirdU6fkfeRWvqXFIcLWhhutu31oa4yjeo-KHS_nq85e1F1YHWyI61ujE5kQ6O0JzKX_qAdvkh5UqfQZbjA |
| PubMed reference number | 17989078v1 |
| Volume Number | 29 |
| Issue Number | 1 |
| Journal | European heart journal |
| Language | English |
| Access Restriction | Open |
| Subject Keyword | Acute myocardial infarction Alcohol consumption Alcoholic Liver Diseases Behaviorial Habits Beverages Cardiovascular Diseases Cerebrovascular accident Cessation of life Ethanol Forecast of outcome Heart failure Hospitalization Patients |
| Content Type | Text |
| Resource Type | Article |
