Poly(dopamine acrylamide)-co-poly(propargyl acrylamide)-modified titanium surfaces for ‘click’ functionalization

Content Provider	Semantic Scholar
Author	Jiang, Hua Neoh, Koon Gee Kang, En-Tang Fu, Guo Dong
Copyright Year	2012
Abstract	Poly(dopamine acrylamide)-co-poly(propargyl acrylamide) (PDA-co-PPA) copolymers, containing alkyne- and catechol-functionalities, were prepared from reactive poly(pentafluorophenyl acrylate) (PPFA) via functionalization of the pentafluorophenyl-activated ester groups with dopamine hydrochloride and propargylamine. The bifunctional PDA-co-PPA copolymers were then coupled to the titanium (Ti) surface via coordination interaction of the catechol moieties, yielding a functionalizable Ti platform containing 'clickable' alkyne groups on the surface for the copper-catalyzed azide-alkyne 1,3-dipolar cycloaddition (CuAAC) of azide-labeled fluorescein, rhodamine, β-cyclodextrin, poly(ethylene glycol) (PEG), mannose and biotin. The functionalized Ti surfaces from the CuAAC reactions were characterized by fluorescence microscopy (for the rhodamine- and fluorescein-functionalized Ti surfaces), non-specific protein adsorption (for the PEG-grafted Ti surface), specific protein adsorption (for the mannose- and biotin-functionalized Ti surfaces) and host–guest interaction with antibiotics (for the β-cyclodextrin-functionalized Ti surface).
Starting Page	920
Ending Page	927
Page Count	8
File Format	PDF HTM / HTML
DOI	10.1039/C2PY00552B
Volume Number	3
Alternate Webpage(s)	http://www.rsc.org/suppdata/py/c2/c2py00552b/c2py00552b.pdf
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article