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Increased apoptosis in differentiating p 27-deficient mouse embryonic stem cells
| Content Provider | Semantic Scholar |
|---|---|
| Author | Bryjaa, V. Pacherníka, J. Součekd, K. Horvathd, V. Hampla, A. |
| Abstract | In mouse embryonic stem (mES) cells, the expression of p27 is elevated when differentiation is induced. Using mES cells lacking p27 we tested the importance of p27 for the regulation of three critical cellular processes: proliferation, differentiation, and apoptosis. Although cell cycle distribution, DNA synthesis, and the activity of key G1/S-regulating cyclin-dependent kinases remained unaltered in p27-deficient ES cells during retinoic acid-induced differentiation, the amounts of cyclin D2 and D3 in such cells were much lower compared CMLS, Cell. Mol. Life Sci. 61 (2004) 1384–140 |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | https://page-one.live.cf.public.springer.com/pdf/preview/10.1007/s00018-004-4081-4 |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |