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Characterization of ventricular fibrillation based on monophasic action potential morphology in the human heart.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Swartz, J. F. Jones, J. Leighton Fletcher, Ross D. |
| Copyright Year | 1993 |
| Abstract | BACKGROUND Recent studies examining mechanisms of defibrillation have focused on prolongation of graded cellular response duration during refractory period stimulation. This mechanism assumes that defibrillation shocks interact with ventricular cells during the process of repolarization. METHODS AND RESULTS To test this assumption, we examined monophasic action potentials (MAPs) from 171 episodes of induced ventricular dysrhythmia associated with loss of systemic perfusion pressure in 22 patients undergoing nonthoracotomy defibrillator implantation. Ventricular fibrillation (VF)/polymorphic ventricular tachycardia (PVT), defined by an irregular limb lead I morphology, was present in 156 dysrhythmia episodes. Monomorphic ventricular tachycardia (VT), present in the remaining 15 episodes, was associated with regular limb lead morphology. All episodes were examined for MAP cycle length, variation, fractionation, and repolarization. VF/PVT cycle length was 215 +/- 28 msec, with a 14 +/- 7% (33 +/- 20-msec) cycle length variability. Nonfractionated MAP recordings were found in 122 of 156 VF/PVT episodes. Episodes characterized as VF by ECG criteria (n = 136) showed lack of MAP diastole and had a mean cycle length of 213 +/- 27 msec. Episodes characterized as PVT (n = 20) were associated with amiodarone therapy and had occasional MAP diastole and a significantly longer mean cycle length of 257 +/- 22 msec (p < 0.001). Monomorphic VT had a mean cycle length of 261 +/- 29 msec, minimal cycle length variation (1 +/- 3%), absence of MAP fractionation, and consistent degree of repolarization before restimulation. CONCLUSIONS These results suggest that human VF cycle length is limited by cellular refractory periods so that defibrillating shocks interact with cells primarily during their refractory period. |
| File Format | PDF HTM / HTML |
| DOI | 10.1161/01.CIR.87.6.1907 |
| PubMed reference number | 8504503 |
| Journal | Medline |
| Volume Number | 87 |
| Issue Number | 6 |
| Alternate Webpage(s) | http://circ.ahajournals.org/content/circulationaha/87/6/1907.full.pdf |
| Alternate Webpage(s) | https://doi.org/10.1161/01.CIR.87.6.1907 |
| Journal | Circulation |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
