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Effects of cervical spinal cord stimulation on cerebral blood flow in the rat.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Sagher, Oren Huang, D.-L. |
| Copyright Year | 2000 |
| Abstract | OBJECT Spinal cord stimulation (SCS) is frequently used for the treatment of chronic pain. Although the mechanisms by which SCS alleviates pain are unclear, they are believed to involve changes within the dorsal horn of the spinal cord. Spinal cord stimulation has also been found to cause significant vasodilation in the peripheral vasculature. The mechanisms underlying this effect are thought to involve sympathetic blockade. A rostral vasodilatory effect has also been described, but changes in cerebral blood flow (CBF) have been poorly delineated. Using laser Doppler flowmetry (LDF), the authors examined the effects of cervical SCS on CBF in rats. METHODS Cervical SCS was found to result in a significant increase in cortical LDF values (83 +/- 11% [mean +/- standard error of the mean]). The increase in cortical LDF values was not accompanied by a significant increase in systemic blood pressure. Stimulation of the upper cervical spinal cord was more effective in inducing LDF changes than was that of the lower cervical cord. Changes in SDS-induced LDF values were significantly attenuated after spinal cord transection at the cervicomedullary junction and by the administration of the sympathetic blocker hexamethonium. CONCLUSIONS These results indicate that cervical SCS may induce cerebral vasodilation and that this effect may involve indirect effects on vasomotor centers in the brainstem as well as an alteration in sympathetic tone. |
| Starting Page | 1 |
| Ending Page | 4 |
| Page Count | 4 |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | https://thejns.org/downloadpdf/journals/j-neurosurg-spine/93/1/article-p71.pdf |
| PubMed reference number | 10879761v1 |
| Volume Number | 93 |
| Issue Number | 1 |
| Journal | Journal of neurosurgery |
| Language | English |
| Access Restriction | Open |
| Subject Keyword | Brain Stem Cerebrovascular Circulation Cervical segment of spinal cord Cervicomedullary Junction Chronic pain Hexamethonium Laser-Doppler Flowmetry Neck Neurostimulation procedures of spinal cord tissue Peripheral Neuropathy Spinal Cord Injuries Spinal Cord Neoplasms Spinal cord posterior horn Structure of posterior gray horn of spinal cord Ultrasonography, Doppler, Transcranial Vasodilation disorder |
| Content Type | Text |
| Resource Type | Article |
