NDLI: Interplay of tRNA-like structures from plant viral RNAs with partners of the translation and replication machineries.

Please wait, while we are loading the content...

Interplay of tRNA-like structures from plant viral RNAs with partners of the translation and replication machineries.

Content Provider	Semantic Scholar
Author	Giegé, Richard
Copyright Year	1996
Abstract	The surprise was great in the early 1970s when it was shown that valine could be covalently attached to the 3' terminus of the genomic RNA from turnip yellow mosaic virus (TYMV) by valyl-tRNA synthetase (1) and, soon after, that tyrosyland histidyl-tRNA synthetases can aminoacylate the RNAs from brome mosaic virus (BMV) and tobacco mosaic virus (2, 3). The surprise was even greater when it was realized that the sequences and secondary foldings of the anticipated "tRNA" domains deviated markedly from those of canonical tRNAs (reviewed in refs. 4-6; Fig. 1) and that tRNA mimicry was linked with the mandatory presence of pseudoknots, the new type of RNA fold discovered in the tRNA-like domain of TYMV (8) and now found in many other RNAs (9, 10). It was soon conjectured about possible physiological roles of these tRNA-like structures (e.g., refs. 4, 11, and 12). When it was proven that they do not participate in protein synthesis, an easy explanation was to consider tRNA-like structures as insignificant remnants of evolutionary processes, but a more positive viewpoint was to consider them as possible actors during the life cycles of the viruses. On the other hand, the peculiar structural features of tRNA-like structures makes them attractive natural tRNA variants useful for investigating the specificity rules underlying recognition of tRNAs by aminoacyltRNA synthetases (6, 13).
Starting Page	917
Ending Page	918
Page Count	2
File Format	PDF HTM / HTML
Alternate Webpage(s)	http://www.pnas.org/content/93/22/12078.full.pdf
PubMed reference number	8901535v1
Volume Number	93
Issue Number	22
Journal	Proceedings of the National Academy of Sciences of the United States of America
Language	English
Access Restriction	Open
Subject Keyword	Brome mosaic virus Bromus DNA Replication Genetic Translation Process Mandatory - HL7DefinedRoseProperty Mosaic Organism Mosaic Viruses New type Published Comment RNA Rule (guideline) Tobacco Mosaic Virus Turnip yellow mosaic virus Valine Valine-tRNA Ligase histrelin
Content Type	Text
Resource Type	Article

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in