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Non-destructive quantification of pharmaceutical tablet coatings using terahertz pulsed imaging and optical coherence tomography
| Content Provider | Semantic Scholar |
|---|---|
| Author | Zhong, Shuncong Shen, Yaochun Ho, Louise May, Robert K. Zeitler, Jochen Axel Evans, Michael Taday, Philip F. Pepper, Michael Rades, Thomas Gordon, Keith C. Müller, Ronny Kleinebudde, Peter |
| Copyright Year | 2011 |
| Abstract | Optical coherence tomography (OCT) and terahertz pulsed imaging (TPI) are two powerful techniques allowing high quality cross-sectional images from within scattering media to be obtained non- destructively. In this paper, we report experimental results of using OCT and TPI for quantitatively characterizing pharmaceutical tablet coatings in the thickness range of 10-140 mm. We found that the spectral OCT system developed in-house has an axial resolution of 0.9 mm, and is capable of quantifying very thin coatings in the range of 10-60 mm. The upper limit of 60 mm within the tablet coating and core is owed to the strong scattering of OCT light, which has relatively short wavelengths in the range of 0.5-1.0 mm. On the other hand, TPI utilizes terahertz radiation that has substantially long wavelengths in the range of hundreds of microns, and thus is less prone to the scattering problem. Consequently TPI has been demonstrated to be able to quantify thicker coatings in the range of 40-140 mm and beyond. We concluded that OCT and TPI are two complementary analytical techniques for non-destructive and quantitative characterization of pharmaceutical tablet coatings. |
| Starting Page | 361 |
| Ending Page | 365 |
| Page Count | 5 |
| File Format | PDF HTM / HTML |
| DOI | 10.1016/j.optlaseng.2010.11.003 |
| Volume Number | 49 |
| Alternate Webpage(s) | http://www.pssrc.org/downloads/other/Zhong_2011_Opt.%20Laser%20Eng.pdf |
| Alternate Webpage(s) | http://pcwww.liv.ac.uk/~ycshen/Publications/2011-OLE-coating.pdf |
| Alternate Webpage(s) | https://doi.org/10.1016/j.optlaseng.2010.11.003 |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
