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Synaptosomal uptake and release of dopamine in substantia nigra: Effects of γ-aminobutyric acid and substance P
| Content Provider | Semantic Scholar |
|---|---|
| Author | Silbergeld, Ellen Kovner Walters, Judith R. |
| Copyright Year | 1979 |
| Abstract | Nigral tissue prepared as synaptosomes demonstrates both high and low affinity uptake of [3H]dopamine. Recently accumulated [3H]dopamine is releasable by 35 mN K+. Substance P increases both uptake and release of dopamine by nigral synaptosomes; gamma-aminobutyric acid (GABA) inhibits release with no effect on uptake at concentrations less than 10-(4) M. In the striatum, substance P inhibits both uptake and release of dopamine. The results support the existence of dopamine-containing terminals in substantia nigra tissue. The differences in response to substance P and GABA found between nigra and striatum may reflect structural differences in dopamine-containing processes in these areas, related to their proposed origin as dendtritic (substantia nigra) and axonal (striatal) terminal. |
| Starting Page | 119 |
| Ending Page | 126 |
| Page Count | 8 |
| File Format | PDF HTM / HTML |
| DOI | 10.1016/0304-3940(79)91491-5 |
| Alternate Webpage(s) | https://api.elsevier.com/content/article/pii/0304394079914915 |
| Alternate Webpage(s) | https://www.sciencedirect.com/science/article/pii/0304394079914915?dgcid=api_sd_search-api-endpoint |
| PubMed reference number | 460694 |
| Alternate Webpage(s) | https://doi.org/10.1016/0304-3940%2879%2991491-5 |
| Journal | Medline |
| Volume Number | 12 |
| Journal | Neuroscience Letters |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
