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Cervicovaginal anti-HIV antibodies in HIV-seronegative female sex workers in Abidjan, Côte d'Ivoire.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Ghys, Peter Denis Bélec, Laurent Diallo, Mamadou Oury Safiatou Ettiègne-Traoré, Virginie Becquart, Pierre Maurice, Christelle Nkengasong, John N. Coulibaly, I. M. Greenberg, Alan E. Laga, Marie Wiktor, Stefan Z. |
| Copyright Year | 2000 |
| Abstract | OBJECTIVE To detect anti-HIV antibodies in cervicovaginal secretions of HIV-seronegative female sex workers and to evaluate whether the presence of these antibodies is associated with increased sexual exposure. METHODS A cross-sectional study was carried out at a confidential clinic for female sex workers in Abidjan, Côte d'Ivoire. The participants were 342 HIV-seronegative female sex workers in whom a cervicovaginal lavage was collected. The main outcome measures were the detection of antibodies to HIV-1 in cervicovaginal lavages using an in-house and a commercial (Seradyn Sentinel; Calypte Biomedical Corporation, Berkeley, California, USA) enzyme immunoassay; the detection of semen in cervicovaginal lavages; and the assessment of epidemiological and biological markers of sexual exposure to HIV. RESULTS Cervicovaginal anti-HIV antibodies were detected in 7.3 and 29.8% of women using in-house enzyme-linked immunosorbent assay (ELISA) and Seradyn Sentinel respectively. All cervicovaginal secretions found to be positive by in-house ELISA were also positive by Seradyn Sentinel. In a minority of women, ranging from 2.9% by in-house ELISA to 12.3% by Seradyn Sentinel, the anti-HIV antibodies were present in vaginal fluids that did not contain semen. Sexual exposure to HIV was similar in women with anti-HIV antibodies in their semen-free cervicovaginal secretions compared with women without anti-HIV antibodies in their cervicovaginal secretions. CONCLUSIONS Cervicovaginal HIV-specific antibodies were detected in a minority of sexually exposed HIV-seronegative female sex workers in Abidjan. The lack of association between increased sexual exposure to HIV and presence of cervicovaginal HIV-specific antibodies suggests that the production of genital HIV-specific antibodies in exposed seronegative women depends on the ability of individual women to mount specific mucosal immunity to HIV antigens, the determinants of which are currently unknown. |
| File Format | PDF HTM / HTML |
| DOI | 10.1097/00002030-200011100-00025 |
| PubMed reference number | 11101074 |
| Journal | Medline |
| Volume Number | 14 |
| Issue Number | 16 |
| Alternate Webpage(s) | http://www.omsj.org/wp-content/uploads/1128-CervicovaginalAntibodies.pdf |
| Alternate Webpage(s) | https://doi.org/10.1097/00002030-200011100-00025 |
| Journal | AIDS |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
