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The role of preoptic area and anterior hypothalamus and median raphe nucleus on thermoregulatory system in freely moving rats
| Content Provider | Semantic Scholar |
|---|---|
| Author | Ishiwata, Takayuki Hasegawa, Hiroshi Yasumatsu, Mikinobu Akano, Fuminori Aihara, Yasutsugu |
| Copyright Year | 2001 |
| Abstract | To clarify the role of the preoptic area and anterior hypothalamus (PO/AH) on thermoregulatory system and the effects of serotonergic innervation from the median raphe nucleus (MRN) on body temperature (Tb), we perfused tetrodotoxin (TTX) solution into the PO/AH or MRN by using a microdialysis technique at different ambient temperatures (5, 23 and 35 degrees C) in freely moving rats. Tb was continuously monitored by using a telemetry system. In the MRN, perfusion of TTX solution induced significant hypothermia in the normal environment, a greater decrease in Tb during cold exposure and had no effect on Tb during heat exposure. In the PO/AH, perfusion of TTX solution induced significant hyperthermia in normal environment, a greater increase in Tb during heat exposure and had no effect on Tb during cold exposure. Our results indicate that the PO/AH regulates mainly heat loss or inhibits the loci regulating heat production. Furthermore, heat production appears to be regulated by other loci receiving serotonergic innervation from the MRN. |
| Starting Page | 126 |
| Ending Page | 128 |
| Page Count | 3 |
| File Format | PDF HTM / HTML |
| DOI | 10.1016/S0304-3940(01)01865-1 |
| PubMed reference number | 11403973 |
| Journal | Medline |
| Volume Number | 306 |
| Alternate Webpage(s) | https://api.elsevier.com/content/article/pii/S0304394001018651 |
| Alternate Webpage(s) | https://www.sciencedirect.com/science/article/pii/S0304394001018651?dgcid=api_sd_search-api-endpoint |
| Alternate Webpage(s) | https://doi.org/10.1016/S0304-3940%2801%2901865-1 |
| Journal | Neuroscience Letters |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
