Loading...
Please wait, while we are loading the content...
Clinical significance of Smac/DIABLO expression in colorectal cancer.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Endo, Kazuya Kohnoe, Shunji Watanabe, Akihiro Tashiro, Hideya Sakata, Hisanobu Morita, Masaru Kakeji, Yoshihiro Maehara, Yoshihiko |
| Copyright Year | 2009 |
| Abstract | Second mitochondria-derived activator of caspases/direct inhibitor of apoptosis-binding protein with low pI (Smac/DIABLO) is released by mitochondria in response to apoptotic stimuli and is thought to regulate apoptosis by antagonizing inhibitors of apoptosis proteins, which play an important role in sensitization of cancer cells to various therapeutic regimens. The expression of Smac/DIABLO has been demonstrated in various cancer cells, though little is known about its clinical significance with respect to colorectal cancer. The current study was designed to evaluate the relationship between prognosis and Smac/DIABLO expression by clinicopathological analysis of patients with colorectal cancer. Smac/DIABLO expression was evaluated using immunohistochemical staining in 121 consecutive patients with colorectal cancer and the relationship between Smac/DIABLO expression and clinicopathological factors was analyzed. Smac/DIABLO-positive expression was detected in 80 of the 121 patients (66%). The incidence of lymph node and distant metastasis in Smac/DIABLO-negative cancer was significantly higher than that in Smac/DIABLO-positive cancer (P=0.0004 and P=0.003, respectively). While univariate analysis showed that survival in patients with Smac/DIABLO-negative expression was significantly poorer than in Smac/DIABLO-positive cases (P<0.0001), Smac/DIABLO-negative expression was a prognostic indicator independent of Dukes' staging and lymph node metastasis by multivariate analysis. This study proposes that the decrease of Smac/DIABLO expression is an independent factor determining the poorer prognosis of patients with colorectal cancer. |
| Starting Page | 96 |
| Ending Page | 106 |
| Page Count | 11 |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | https://www.spandidos-publications.com/or/21/2/351/download |
| PubMed reference number | 19148507v1 |
| Volume Number | 21 |
| Issue Number | 2 |
| Journal | Oncology reports |
| Language | English |
| Access Restriction | Open |
| Subject Keyword | Anatomic Node Apoptosis Colorectal Carcinoma DIABLO gene Distant Metastasis Dukes classification Eighty Forecast of outcome Lymph Node Tissue Neoplasms Non-Small Cell Lung Carcinoma Patients Sensitization (observable entity) Smac Mimetic GDC-0917 Staining method cancer cell caspase lymph node metastases lymph nodes |
| Content Type | Text |
| Resource Type | Article |
