NDLI: Effects of Opuntia humifusa Supplementation on Lipid Peroxidation and SOD Protein Expression in the Liver, Kidney, and Skeletal Muscle of Rats Fed a High-fat Diet

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Effects of Opuntia humifusa Supplementation on Lipid Peroxidation and SOD Protein Expression in the Liver, Kidney, and Skeletal Muscle of Rats Fed a High-fat Diet

Content Provider	Semantic Scholar
Author	Kwon, Daekeun Kang, Junyong Park, Jinho Ryu, Sungpil Song, Youngju
Copyright Year	2012
Abstract	This study was conducted to investigate the effects of Opuntia humifusa supplementation on lipid peroxidation and superoxide dismutase (SOD) protein expression at resting state in various organs of rats fed a high-fat diet. Sixteen Sprague-Dawley male rats, 6 weeks of age, were randomly divided into two groups: a control diet group (CG, n=8) and an experimental diet group (EG, n=8). They were given a high-fat diet (CG) or a diet supplemented with 5% of O. humifusa (EG) or 8 weeks. The results showed that the malondialdehyde (MDA) levels of the kidney and the liver were significantly lower in the EG group than in the CG group (p<0.01). In addition, the MDA levels in the skeletal muscle of the EG group tended to be lower than those in the CG group, but this difference was not significant. The Cu, Zn-SOD protein expression in the kidney of the EG group was significantly increased compared with that of the CG group (p<0.01). The Mn-SOD protein expression in the skeletal muscle of the EG group was significantly increased compared with that of the CG group (p<0.01). These results suggest that O. humifusa supplementation has antioxidative properties, which are exerted in a specific organ manner, and that it inhibits the action of lipid peroxidation and the expression of SOD in rats fed a high-fat diet.
Starting Page	857
Ending Page	862
Page Count	6
File Format	PDF HTM / HTML
DOI	10.5352/JLS.2012.22.7.857
Volume Number	22
Alternate Webpage(s)	http://ocean.kisti.re.kr/downfile/volume/ksls/SMGHBM/2012/v22n7/SMGHBM_2012_v22n7_857.pdf
Alternate Webpage(s)	https://doi.org/10.5352/JLS.2012.22.7.857
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article

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