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Electrospun fibrous web of collagen–apatite precipitated nanocomposite for bone regeneration
| Content Provider | Semantic Scholar |
|---|---|
| Author | Song, Ju-Ha Kim, Hyoun-Ee Kim, Hae-Won |
| Copyright Year | 2008 |
| Abstract | Electrospinning is regarded as a facile tool to generate biomaterials into a nanofibrous structure. Herein a nanofibrous web constituted of collagen and hydroxyapatite (HA) was produced from their co-precipitated nanocomposite solution by using the electrospinning method. The co-precipitated sol was freeze-dried and the dried product was dissolved in an organic solvent for the electrospinning. The electrospun web showed a well-developed nanofibrous structure with HA contents of up to 20 wt%. The internal structure of the collagen–20 wt%HA nanofiber revealed highly elongated apatite nanocrystallines precipitated within the collagen matrix. However, above the HA content of 30 wt% the nanofibrous structure could not be preserved due to the formation of beads. The MC3T3-E1 osteoblastic cells were shown to adhere and grow actively on the collagen–HA nanofibrous web. The alkaline phosphatase (ALP) activity expressed by the cells on the collagen–20 wt%HA nanofiber was lower at day 7, but was higher at day 14 than that on the pure collagen nanofiber. Based on the study, the newly-developed collagen–HA nanofiber may be useful as a cell supporting substrate in bone regeneration area. |
| Starting Page | 1241 |
| Ending Page | 1242 |
| Page Count | 2 |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | http://slim.snu.ac.kr/pdf/240.pdf |
| PubMed reference number | 18360796v1 |
| Alternate Webpage(s) | https://doi.org/10.1007/s10856-008-3420-7 |
| DOI | 10.1007/s10856-008-3420-7 |
| Journal | Journal of materials science. Materials in medicine |
| Volume Number | 19 |
| Issue Number | 8 |
| Language | English |
| Access Restriction | Open |
| Subject Keyword | Alkaline Phosphatase Apatites Bead Dosage Form Biologic Preservation Bone Regeneration Collagen Diseases Durapatite Freeze Drying Nanocomposites Nanofibers Natural regeneration Organic solvent product contents - HtmlLinkType |
| Content Type | Text |
| Resource Type | Article |
