Chemiluminescence from the biomimetic reaction of 1,2,4-trioxolanes and 1,2,4,5-tetroxanes with ferrous ions

Content Provider	Semantic Scholar
Author	Kazakov, Dmitri V. Timerbaev, Andrei R. Safarov, Farit E. Nazirov, T. I. Kazakova, Oxana B. Ishmuratov, Gumer Yu. Terent’ev, Alexander O. Borisov, Dmitry A. Tolstikov, Alexander G. Tolstikov, Genrikh A. Adam, Waldemar
Copyright Year	2012
Abstract	The 1,2,4-trioxolane and 1,2,4,5-tetroxane pharmacophores are currently considered as the next generation of synthetic antimalarial drugs. This fact has stimulated the exploration of the chemiluminescence displayed by these cyclic peroxides in biomimetic reactions with Fe(II). The CL has been induced by FeSO4 and/or the FeCl3/L-cysteine/Rhodamine G system in aqueous (50%) acetonitrile. The light emission in the visible spectral region has been recorded for triterpenoid-based 1,2,4-trioxolanes, purely synthetic ozonide OZ03, bicyclic 1,2,4,5-tetroxanes, a tetroxane derived from deoxycholic acid, the diperoxide of trifluoroacetone, as well as the natural artemisinin. The herein discovered CL provides a promising perspective for the study of pharmacologically active peroxides in biomedical applications.
Starting Page	107
Ending Page	110
Page Count	4
File Format	PDF HTM / HTML
DOI	10.1039/C1RA00784J
Volume Number	2
Alternate Webpage(s)	http://www.rsc.org/suppdata/ra/c1/c1ra00784j/c1ra00784j.pdf
Alternate Webpage(s)	https://doi.org/10.1039/C1RA00784J
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article