The role of nitric oxide in striatal acetylcholine release induced by N-methyl-d-aspartate

Content Provider	Semantic Scholar
Author	Ikarashi, Yasushi Takahashi, Akira Ishimaru, Hirohisa Shiobara, Takemi Maruyama, Yuji
Copyright Year	1998
Abstract	Effect of nitric oxide (NO) on striatal acetylcholine (ACh) release induced by N-methyl-D-aspartate (NMDA) was investigated in freely moving rats by means of microdialysis. NMDA caused a significant increase in ACh release in the striatum, which was blocked by the specific NMDA receptor antagonists, (+/-)-3-(2-carboxypiperazin-4-yl)-propyl-1-phosphonic acid (CPP) and (+)-5-methyl-10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5,10-imine hydrogen maleate (MK-801), indicating that agonist-evoked increase in ACh release in the striatum was through an NMDA receptor-mediated mechanism. NG-monomethyl-L-arginine acetate salt (L-NMMA; a NO synthase inhibitor) facilitated NMDA-evoked increase in ACh release, while L-arginine (the precursor of NO) inhibited the ACh release. The increase by L-NMMA of ACh release induced by the NMDA was also blocked by L-arginine. These results suggest that NO induced by NMDA receptor-mediated mechanism in cholinergic neurons may mediate an inhibitory regulation of ACh release.
Starting Page	255
Ending Page	261
Page Count	7
File Format	PDF HTM / HTML
DOI	10.1016/S0197-0186(98)00029-1
Alternate Webpage(s)	https://api.elsevier.com/content/article/pii/S0197018698000291
Alternate Webpage(s)	https://www.sciencedirect.com/science/article/pii/S0197018698000291?dgcid=api_sd_search-api-endpoint
PubMed reference number	9759921
Alternate Webpage(s)	https://doi.org/10.1016/S0197-0186%2898%2900029-1
Journal	Medline
Volume Number	33
Journal	Neurochemistry International
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article