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Area at risk can be assessed by iodine-123-meta-iodobenzylguanidine single-photon emission computed tomography after myocardial infarction: a prospective study
| Content Provider | Semantic Scholar |
|---|---|
| Author | Hedon, Christophe Huet, Fabien Bouallègue, Fayçal Ben Vernhet, Hélène Macia, Jean Christophe Cung, T. T. Leclercq, Florence Cade, Stéphane Cransac, Frédéric Lattuca, Benoît Vandenberghe, D’ Arcy Bourdon, Aurélie Benkiran, Meriem Vauchot, Fabien Gervasoni, Richard D’estanque, Emmanuel Mariano-Goulart, Denis Roubille, François |
| Copyright Year | 2018 |
| Abstract | Background Myocardial salvage is an important surrogate endpoint to estimate the impact of treatments in patients with ST-segment elevation myocardial infarction (STEMI). Aim The aim of this study was to evaluate the correlation between cardiac sympathetic denervation area assessed by single-photon emission computed tomography (SPECT) using iodine-123-meta-iodobenzylguanidine (123I-MIBG) and myocardial area at risk (AAR) assessed by cardiac magnetic resonance (CMR) (gold standard). Patients and methods A total of 35 postprimary reperfusion STEMI patients were enrolled prospectively to undergo SPECT using 123I-MIBG (evaluates cardiac sympathetic denervation) and thallium-201 (evaluates myocardial necrosis), and to undergo CMR imaging using T2-weighted spin-echo turbo inversion recovery for AAR and postgadolinium T1-weighted phase sensitive inversion recovery for scar assessment. Results 123I-MIBG imaging showed a wider denervated area (51.1±16.0% of left ventricular area) in comparison with the necrosis area on thallium-201 imaging (16.1±14.4% of left ventricular area, P<0.0001). CMR and SPECT provided similar evaluation of the transmural necrosis (P=0.10) with a good correlation (R=0.86, P<0.0001). AAR on CMR was not different compared with the denervated area (P=0.23) and was adequately correlated (R=0.56, P=0.0002). Myocardial salvage evaluated by SPECT imaging (mismatch denervated but viable myocardium) was significantly higher than by CMR (P=0.02). Conclusion In patients with STEMI, 123I-MIBG SPECT, assessing cardiac sympathetic denervation may precisely evaluate the AAR, providing an alternative to CMR for AAR assessment. |
| Starting Page | 489 |
| Ending Page | 494 |
| Page Count | 6 |
| File Format | PDF HTM / HTML |
| PubMed reference number | 29194288 |
| Journal | Medline |
| Volume Number | 39 |
| Alternate Webpage(s) | http://scinti.edu.umontpellier.fr/files/2017/12/NMC_2017.pdf |
| Alternate Webpage(s) | https://doi.org/10.1097/MNM.0000000000000782 |
| Journal | Nuclear medicine communications |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
