NDLI: It is the plasma renin activity level that counts, not stoichiometry.

Content Provider	Semantic Scholar
Author	Sealey, Jean E. Laragh, John H.
Copyright Year	2008
Abstract	To the Editor: We disagree with Danser et al1 that, in patients taking the renin inhibitor aliskiren, “it is the stoichiometry that counts, not the rise in renin.” In fact, plasma renin activity (PRA) is a more explicit indicator than stoichiometry. A PRA fall during aliskiren means that renal renin secretion did not increase by much. A PRA rise means that the increase in renal renin secretion was large enough to overwhelm the aliskiren blockade of PRA. It is that simple. …
Starting Page	248
Ending Page	258
Page Count	11
File Format	PDF HTM / HTML
DOI	10.1161/HYPERTENSIONAHA.108.116319
Alternate Webpage(s)	http://hyper.ahajournals.org/content/hypertensionaha/52/2/e20.full.pdf?download=true
PubMed reference number	18606895
Alternate Webpage(s)	https://doi.org/10.1161/HYPERTENSIONAHA.108.116319
Journal	Medline
Volume Number	52
Issue Number	2
Journal	Hypertension
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article

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