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Signaling Role of Prokineticin 2 on the Estrous Cycle of Female Mice
| Content Provider | Semantic Scholar |
|---|---|
| Author | Xiao, Ling Ling Zhang, Chengkang Li, Xiaoyong Gong, Shiaoching Hu, Renming Balasubramanian, Ravikumar William F. Crowley W. Hastings, Michael H. |
| Copyright Year | 2014 |
| Abstract | The possible signaling role of prokineticin 2 (PK2) and its receptor, prokineticin receptor 2 (PKR2), on female reproduction was investigated. First, the expression of PKR2 and its co-localization with estrogen receptor (ERα) in the hypothalamus was examined. Sexually dimorphic expression of PKR2 in the preoptic area of the hypothalamus was observed. Compared to the male mice, there was more widespread PKR2 expression in the preoptic area of the hypothalamus in the female mice. The likely co-expression of PKR2 and ERα in the preoptic area of the hypothalamus was observed. The estrous cycles in female PK2-null, and PKR2-null heterozygous mice, as well as in PK2-null and PKR2-null compound heterozygous mice were examined. Loss of one copy of PK2 or PKR2 gene caused elongated and irregular estrous cycle in the female mice. The alterations in the estrous cycle were more pronounced in PK2-null and PKR2-null compound heterozygous mice. Consistent with these observations, administration of a small molecule PK2 receptor antagonist led to temporary blocking of estrous cycle at the proestrous phase in female mice. The administration of PKR2 antagonist was found to blunt the circulating LH levels. Taken together, these studies indicate PK2 signaling is required for the maintenance of normal female estrous cycles. |
| File Format | PDF HTM / HTML |
| DOI | 10.1371/journal.pone.0090860 |
| PubMed reference number | 24633064 |
| Journal | Medline |
| Volume Number | 9 |
| Alternate Webpage(s) | https://dash.harvard.edu/bitstream/handle/1/12064464/3954593.pdf?isAllowed=y&sequence=1 |
| Alternate Webpage(s) | https://dash.harvard.edu/bitstream/handle/1/12064464/3954593.pdf?sequence=1 |
| Alternate Webpage(s) | http://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0090860&type=printable |
| Alternate Webpage(s) | https://doi.org/10.1371/journal.pone.0090860 |
| Journal | PloS one |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
