NDLI: Changes in histone acetylation during mouse oocyte meiosis

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Changes in histone acetylation during mouse oocyte meiosis

Content Provider	Semantic Scholar
Author	Kim, Jin-Moon Liu, Honglin Tazaki, Mayuko Nagata, Masao Aoki, Fugaku
Copyright Year	2003
Abstract	We examined global changes in the acetylation of histones in mouse oocytes during meiosis. Immunocytochemistry with specific antibodies against various acetylated lysine residues on histones H3 and H4 showed that acetylation of all the lysines decreased to undetectable or negligible levels in the oocytes during meiosis, whereas most of these lysines were acetylated during mitosis in preimplantation embryos and somatic cells. When the somatic cell nuclei were transferred into enucleated oocytes, the acetylation of lysines decreased markedly. This type of deacetylation was inhibited by trichostatin A, a specific inhibitor of histone deacetylase (HDAC), thereby indicating that HDAC is able to deacetylate histones during meiosis but not during mitosis. Meiosis-specific deacetylation may be a consequence of the accessibility of HDAC1 to the chromosome, because HDAC1 colocalized with the chromosome during meiosis but not during mitosis. As histone acetylation is thought to play a role in propagating the gene expression pattern to the descendent generation during mitosis, and the gene expression pattern of differentiated oocytes is reprogrammed during meiosis to allow the initiation of a new program by totipotent zygotes of the next generation, our results suggest that the oocyte cytoplasm initializes a program of gene expression by deacetylating histones.
Starting Page	37
Ending Page	46
Page Count	10
File Format	PDF HTM / HTML
PubMed reference number	12835313
Volume Number	162
Journal	The Journal of cell biology
Alternate Webpage(s)	http://jcb.rupress.org/content/jcb/162/1/37.full.pdf
Alternate Webpage(s)	https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/50/bb/200303047.PMC2172711.pdf
Alternate Webpage(s)	http://ftp.ncbi.nlm.nih.gov/pub/pmc/50/bb/200303047.PMC2172711.pdf
Alternate Webpage(s)	http://jcb.rupress.org/content/jcb/162/1/37.full.pdf?with-ds=yes
Language	English
Access Restriction	Open
Subject Keyword	Cell Nucleus Deacetylation Diploid Cell Embryo Gene Expression Histone Acetylation Histone Deacetylase Histones Lysine Meiosis Mitosis Oocytes Preimplantation Diagnosis Reprogram Structure of zygote trichostatin A
Content Type	Text
Resource Type	Article

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