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WAY 120,491 activates ATP-sensitive potassium channels in rat tail artery.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Furspan, Philip B. |
| Copyright Year | 1992 |
| Abstract | WAY 120,491 lowers blood pressure in a number of animal models. Its mechanism of action appears to be the selective opening of K+ channels in vascular smooth muscle cells. The patch clamp technique was used to determine the specific K+ channel affected by WAY 120,491 in isolated tail artery cells of the rat. In the inside-out configuration, WAY 120,491 caused a dose dependent partial reversal of the ATP-induced inactivation of channel activity. Glyburide (10 microM) almost completely inhibited the effect of WAY 120,491. WAY 120,491 had no effect on Ca-activated K+ channels inactivated by the absence of Ca2+. In the whole cell configuration, 10 microM WAY 120,491 increased outward K+ current. 10 microM glyburide completely reversed the increase in current. WAY 120,491 appears to be a relatively specific activator of ATP-sensitive K+ channels in vascular smooth muscle. |
| Starting Page | 21 |
| Ending Page | 33 |
| Page Count | 13 |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | https://deepblue.lib.umich.edu/bitstream/handle/2027.42/29725/0000061.pdf?isAllowed=y&sequence=1 |
| PubMed reference number | 1478268v1 |
| Volume Number | 223 |
| Issue Number | 2-3 |
| Journal | European journal of pharmacology |
| Language | English |
| Access Restriction | Open |
| Subject Keyword | Adenosine Triphosphate Animal Model Calcium ion Dietary Potassium Drug Kinetics Glyburide Muscle Cells Muscle, Smooth, Vascular Myocytes, Smooth Muscle Potassium Channel Smooth muscle (tissue) channel activity |
| Content Type | Text |
| Resource Type | Article |
