NDLI: Activation of tuberculostatic macrophage functions by gamma interferon, interleukin-4, and tumor necrosis factor.

Content Provider	Semantic Scholar
Author	Flesch, I. E. Kaufmann, Stefan H. E.
Copyright Year	1990
Abstract	The capacity of the cytokines gamma interferon (IFN-gamma), interleukin-4 (IL-4), and tumor necrosis factor (TNF) to activate tuberculostatic functions in murine bone marrow-derived macrophages (BMM phi) was investigated. In confirmation of earlier findings, IFN-gamma rendered BMM phi capable of inhibiting subsequent infection with Mycobacterium bovis. In contrast, IL-4 and TNF failed to inhibit mycobacterial growth. However, in already infected BMM phi, tuberculostasis was induced by subsequent stimulation with IL-4. Although TNF alone was ineffective, it showed synergy with IFN-gamma in the stimulation of tuberculostasis. Our data suggest that not only IFN-gamma but also IL-4 and TNF participate in the control of mycobacterial growth.
File Format	PDF HTM / HTML
DOI	10.1128/iai.58.8.2675-2677.1990
PubMed reference number	2115027
Journal	Medline
Volume Number	58
Issue Number	8
Alternate Webpage(s)	http://iai.asm.org/content/58/8/2675.full.pdf
Alternate Webpage(s)	https://doi.org/10.1128/iai.58.8.2675-2677.1990
Journal	Infection and immunity
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article

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