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Single photon emission computed tomography myocardial perfusion imaging to detect cardiac allograft vasculopathy.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Thompson, David A. Koster, Matthew Wagner, Robert Herman Heroux, Alain L. Barron, John T. |
| Copyright Year | 2012 |
| Abstract | AIMS Cardiac allograft vasculopathy (CAV) is a major cause of morbidity and mortality in cardiac transplant recipients. This study evaluates the usefulness of single photon emission computed tomography (SPECT) and various SPECT-derived diastolic variables to detect CAV in heart transplant patients. METHODS AND RESULTS A retrospective review of 141 SPECT studies with corresponding coronary angiograms within 12 months was performed on 99 transplant recipients. Diastolic function was assessed using computer-derived measures of peak filling rate (PFR), time to peak filling rate (TPFR), and mean first one-third filling rate (MFR/3). Angiography identified CAV in 53 of the 141 studies (38%). Of the 53, SPECT identified 7 with reversible myocardial defects (sensitivity 13%) and stress-induced electrocardiographic evidence of ischaemia was seen in one patient (sensitivity 2%). SPECT imaging was negative in 86 of the 88 negative coronary angiograms (specificity 98%). The positive predictive value and negative predictive value were 78 and 65%, respectively. If a more stringent definition of CAV was used (≥70% stenosis), the sensitivity and specificity were unchanged (14 and 98%, respectively). There was no statistical difference in diastolic variables between patients with or without angiographic evidence of CAV in regard to PFR (3.57 ± 1.14 vs. 3.18 ± 1.21 EDV/s, P = 0.90), TPFR (149 ± 32 vs. 153 ± 43 ms, P = 0.33), or MFR/3 (1.37 ± 0.43 vs. 1.27 ± 0.42 EDV/s, P = 0.94). CONCLUSION Adenosine stress/rest technetium-99m tetrofosmin-gated SPECT is not a sensitive test for detection of CAV in heart transplant recipients. Diastolic dysfunction, as assessed by SPECT, was not shown to be associated with development of CAV. |
| File Format | PDF HTM / HTML |
| DOI | 10.1093/ejechocard/jer270 |
| PubMed reference number | 22143401 |
| Journal | Medline |
| Volume Number | 13 |
| Issue Number | 3 |
| Alternate Webpage(s) | https://watermark.silverchair.com/jer270.pdf?token=AQECAHi208BE49Ooan9kkhW_Ercy7Dm3ZL_9Cf3qfKAc485ysgAAAlAwggJMBgkqhkiG9w0BBwagggI9MIICOQIBADCCAjIGCSqGSIb3DQEHATAeBglghkgBZQMEAS4wEQQMFQl9ckYBIcesUSD5AgEQgIICA7aQwZXPyWydf4Cxq85jQ78oLG7F34ujDn5hw5VU2S6V6_WDrLra-gBm7hb-gbTvR3is5fl4U1sfZjhw6Va8787foO_o_qrHJYiX6ktb8JlJfvaK3_3xUS9CwfcBNG8zr30TEfThQ0JR8gMCXgek5OqOILQzacHwssvJ2YiWIoJHQr8uJt8uCmgHaam3UjnQ0fha22fzdS7NFHTpiYmEgQ3QKaxlFh2is9PF_B41oxza9uXqi1EZtyNx1ipBOpTo8CUDBkTJ5IExTlBa0vyz3Is5RRAVtRCcTHx6pJHSh_OKWyrgVTdwQ0eQuWcZuMjbmdEjup1XPxflLQV4dVQVcMd6GAmEVk7_DEtRIZWrY8vrg3sJBejtzsknXgMYNCmZ205jPMKOIPaFFQbwPnL6OfWPyLNbrxBrhY2RSczb2HTGKeMhbzEc2h-skM1PIMCn4bjJU8s1C0riCOBy6DZkebK7tJ8U9qGU1jQ-SRr1B-xztyI9e-2J3rXRbr2bScwd9yB0Foo5GM10M6cDNgPbxUS61PlYeQgOrqy3Pp2T_ujggVjyk8RXy8Sh-dPjZwkWPoOZ1YSx-L9d_75N088olbhA53e4UjAt7Y3V0N6FzlcClogf3u03oWOyZSAMnY8doImLOp89s9FeUEVrpkx-x3ZcLSX-kxXo43xxou6ek2KhDNXY |
| Alternate Webpage(s) | https://doi.org/10.1093/ejechocard%2Fjer270 |
| Journal | European heart journal cardiovascular Imaging |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
