NDLI: Frizzled 8 promotes the cell proliferation and metastasis of renal cell carcinoma

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Frizzled 8 promotes the cell proliferation and metastasis of renal cell carcinoma

Content Provider	Semantic Scholar
Author	Yang, Qiwei Wang, Ye Pan, Xiuwu Ye, Jing Ping Gan, Sishun Qu, Fajun Chen, Lu Chu, Chuanmin Gao, Yi Cui, Xingang
Copyright Year	2017
Abstract	Recent reports have shown a rapid rise in the incidence of renal cell carcinoma (RCC), and Wnt (Wingless-related integration site) signaling pathway is important in RCC. Frizzled 8 (FZD8) is a member of Frizzled (FZD) receptor family which could activate canonical or non-canonical Wnt/β-catenin pathways. Nevertheless, the role of FZD8 in RCC is poorly investigated. The immunohistochemical analysis showed high expression of FZD8 in RCC tissues compared with peri-tumor tissues. FZD8 knockdown decreased the ability of proliferation and metastasis of RCC cells. Research revealed that the FZD8 regulated the transcription of Cyclin D1, c-Myc, and could promote the epithelial to mesenchymal transition (EMT) by mediating Vimentin and Snail through the Wnt/β-catenin signaling pathway. In addition, the results of our experiment revealed that FZD8 is involved in the regulation of non-canonical Wnt signaling pathway. These data suggested that the expression of FZD8 may play an important role in the proliferation and metastasis of RCC, and serve as a putative promising drug target for human RCC therapy.
Starting Page	78989
Ending Page	79002
Page Count	14
File Format	PDF HTM / HTML
Alternate Webpage(s)	http://www.oncotarget.com/index.php?journal=oncotarget&op=download&page=article&path%5B%5D=20742&path%5B%5D=66075
PubMed reference number	5668014
Alternate Webpage(s)	https://doi.org/10.18632/oncotarget.20742
DOI	10.18632/oncotarget.20742
Journal	Oncotarget
Volume Number	8
Language	English
Access Restriction	Open
Subject Keyword	Activation action Body tissue Cell Proliferation Drug Delivery Systems Epithelial cell of renal tubule FZD8 gene Fzd8 protein, human Neoplasms Renal Cell Carcinoma Signal Transduction Pathways epithelial to mesenchymal transition non-canonical Wnt signaling pathway
Content Type	Text
Resource Type	Article

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