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Human chorionic gonadotropin radioantibodies in the radioimmunodetection of cancer and for disclosure of occult metastases.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Goldenberg, D. M. Kim, Edmund E. Deland, F. H. |
| Copyright Year | 1981 |
| Abstract | Radioimmunodetection (RaID) of tumors containing human chorionic gonadotropin (hCG; choriogonadotropin) was evaluated in 25 patients by injecting 131I-labeled goat antibody IgG against hCG and performing total-body photoscans with a gamma scintillation camera 24 and 48 hr later. All 10 testicular cancer patients with proven tumor sites had positive RaID results, whereas three cases without known tumor were negative. Four patients with hydatidiform mole and one with degenerative products of conception showed positive RaID results consistent with elevated serum hCG titers. Two putatively false-positive results were obtained in patients with lung or ovarian cancer, whereas a false-negative metastasis to the liver of a patient with lung cancer and an elevated serum hCG titer was observed. Of 14 tumor sites found by RaID in 10 testicular cancer patients, 4 were revealed by RaID prior to any other detection method used and provided a lead time to definitive diagnosis by other measures of a few days to greater than 1 yr. Although a number of patients had high serum hCG levels, even exceeding 3 microgram/ml, the xenogeneic antibody was capable of localizing in tumor. No adverse effects were noted in any of the patients studied. Thus, hCG RaID appears to be a safe and effective method of detecting and locating hCG-producing tumors and has been found to disclose occult testicular cancers. |
| Starting Page | 97 |
| Ending Page | 104 |
| Page Count | 8 |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | http://www.pnas.org/content/78/12/7754.full.pdf |
| PubMed reference number | 6278487v1 |
| Volume Number | 78 |
| Issue Number | 12 |
| Journal | Proceedings of the National Academy of Sciences of the United States of America |
| Language | English |
| Access Restriction | Open |
| Subject Keyword | Abnormal degeneration Carcinoma of lung Disclosure Gamma Cameras Gonadotropins HYPERTRICHOSIS, CONGENITAL GENERALIZED Hydatidiform Mole Malignant neoplasm of ovary Malignant neoplasm of testis Neoplasms by Site Patients Radioimmunodetection Receptors, LH Recombinant Human Chorionic Gonadotropin Structure of parenchyma of lung Titer Tracer liver metastases ovarian neoplasm |
| Content Type | Text |
| Resource Type | Article |
