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Evaluation of the immune benefits of two probiotic strains Bifidobacterium animalis ssp. lactis, BB-12® and Lactobacillus paracasei ssp. paracasei, L. casei 431® in an influenza vaccination model: a randomised, double-blind, placebo-controlled study.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Rizzardini, Giuliano Eskesen, Dorte Calder, Philip C. Capetti, Amedeo Ferdinando Jespersen, Lillian Clerici, Mario |
| Copyright Year | 2012 |
| Abstract | The present study investigated the ability of Bifidobacterium animalis ssp. lactis (BB-12®) and Lactobacillus paracasei ssp. paracasei (L. casei 431®) to modulate the immune system using a vaccination model in healthy subjects. A randomised, double-blind, placebo-controlled, parallel-group study was conducted in 211 subjects (56 % females, mean age 33·2 (sd 13·1) years). Subjects consumed a minimum of 10⁹ colony-forming units of BB-12® (capsule) or L. casei 431® (dairy drink) or a matching placebo once daily for 6 weeks. After 2 weeks, a seasonal influenza vaccination was given. Plasma and saliva samples were collected at baseline and after 6 weeks for the analysis of antibodies, cytokines and innate immune parameters. Changes from baseline in vaccine-specific plasma IgG, IgG1 and IgG3 were significantly greater in both probiotic groups v. the corresponding placebo group (L. casei 431®, P = 0·01 for IgG; P < 0·001 for remaining comparisons). The number of subjects obtaining a substantial increase in specific IgG (defined as ≥ 2-fold above baseline) was significantly greater in both probiotic groups v. placebo (BB-12®, P < 0·001 for IgG, IgG1 and IgG3; L. casei 431®, P < 0·001 for IgG1 and IgG3). Significantly greater mean fold increases for vaccine-specific secretory IgA in saliva were observed in both probiotic groups v. placebo (BB-12®, P = 0·017; L. casei 431®, P = 0·035). Similar results were observed for total antibody concentrations. No differences were found for plasma cytokines or innate immune parameters. Data herein show that supplementation with BB-12® or L. casei 431® may be an effective means to improve immune function by augmenting systemic and mucosal immune responses to challenge. |
| File Format | PDF HTM / HTML |
| DOI | 10.1017/S000711451100420X |
| PubMed reference number | 21899798 |
| Journal | Medline |
| Volume Number | 107 |
| Issue Number | 6 |
| Alternate Webpage(s) | https://www.cambridge.org/core/services/aop-cambridge-core/content/view/37AF5CBDFE755064E97C8C75E7B8F5D4/S000711451100420Xa.pdf/evaluation_of_the_immune_benefits_of_two_probiotic_strains_bifidobacterium_animalis_ssp_lactis_bb12_and_lactobacillus_paracasei_ssp_paracasei_l_casei_431_in_an_influenza_vaccination_model_a_randomised_doubleblind_placebocontrolled_study.pdf |
| Alternate Webpage(s) | https://sprimwpcdn.azureedge.net/sprimwebassets/sprimcms/wp-content/uploads/sites/3/2017/02/21-Evaluation-of-the-immune-benefits.pdf |
| Alternate Webpage(s) | https://doi.org/10.1017/S000711451100420X |
| Journal | The British journal of nutrition |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
