Intracerebroventricular Transplantation of Human Mesenchymal Stem Cells Induced to Secrete Neurotrophic Factors Attenuates Clinical Symptoms in a Mouse Model of Multiple Sclerosis

Content Provider	Semantic Scholar
Author	Barhum, Yael Gai-Castro, Sharon Bahat-Stromza, Merav Barzilay, Ran Melamed, Eldad Offen, Daniel
Copyright Year	2009
Abstract	Stem cell-based therapy holds great potential for future treatment of multiple sclerosis (MS). Bone marrow mesenchymal stem cells (MSCs) were previously reported to ameliorate symptoms in mouse MS models (experimental autoimmune encephalomyelitis, EAE). In this study, we induced MSCs to differentiate in vitro into neurotrophic factor-producing cells (NTFCs). Our main goal was to examine the clinical use of NTFCs on EAE symptoms. The NTFCs and MSCs were transplanted intracerebroventricularly (ICV) to EAE mice. We found that NTFCs transplantations resulted in a delay of symptom onset and increased animal survival. Transplantation of MSCs also exerted a positive effect but to a lesser extent. In vitro analysis demonstrated the NTFCs' capacity to suppress mice immune cells and protect neuronal cells from oxidative insult. Our results indicate that NTFCs-transplanted ICV delay disease symptoms of EAE mice, possibly via neuroprotection and immunomodulation, and may serve as a possible treatment to MS.
Starting Page	129
Ending Page	137
Page Count	9
File Format	PDF HTM / HTML
DOI	10.1007/s12031-009-9302-8
PubMed reference number	19902385
Journal	Medline
Volume Number	41
Alternate Webpage(s)	http://www.brainstorm-cell.com/technology/publications/intracerebroventricular-transplantation-human-mesenchymal-stem-cells-induced-secrete-neurotrophic-factors-attenuates-clinical-symptoms-mouse-model-multiple-sclerosis/?dl=1
Alternate Webpage(s)	https://doi.org/10.1007/s12031-009-9302-8
Journal	Journal of Molecular Neuroscience
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article