NDLI: Intraocular gene transfer of ciliary neurotrophic factor prevents death and increases responsiveness of rod photoreceptors in the retinal degeneration slow mouse.

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Intraocular gene transfer of ciliary neurotrophic factor prevents death and increases responsiveness of rod photoreceptors in the retinal degeneration slow mouse.

Content Provider	Semantic Scholar
Author	Cayouette, Michel Behn, Darren Sendtner, Michael Lachapelle, Pierre Gravel, Claude
Copyright Year	1998
Abstract	Several mutations causing both photoreceptor degeneration and malfunction have been identified in humans and animals. Although intraocular injection of trophic factors has been shown to reduce photoreceptor death in a few conditions of rapid photoreceptor loss, it is unclear whether long-term beneficial changes in functional properties of affected photoreceptors can be obtained by treatment with these factors. The rds/rds mouse is a spontaneous mutant bearing a null mutation in the rds/peripherin gene, which is linked to many forms of dominant retinal degenerations in humans. Here, we report that intraocular adenovirus-mediated gene transfer of ciliary neurotrophic factor (CNTF) in this mutant reduces photoreceptor loss, causes a significant increase in the length of photoreceptor segments, and results in a redistribution and an increase in the retinal content of the photopigment rhodopsin. These effects are accompanied by a significant increase in the amplitude of the a- and b-waves of the scotopic electroretinogram. These results suggest that continuous administration of CNTF could potentially be useful for the treatment of some forms of retinal degeneration.
File Format	PDF HTM / HTML
DOI	10.1523/JNEUROSCI.18-22-09282.1998
PubMed reference number	9801367
Journal	Medline
Volume Number	18
Issue Number	22
Alternate Webpage(s)	http://www.jneurosci.org/content/18/22/9282.full.pdf
Alternate Webpage(s)	http://www.jneurosci.org/content/jneuro/18/22/9282.full.pdf
Alternate Webpage(s)	https://doi.org/10.1523/JNEUROSCI.18-22-09282.1998
Journal	The Journal of neuroscience : the official journal of the Society for Neuroscience
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article

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