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High-frequency oscillatory ventilation versus synchronized intermittent mandatory ventilation plus pressure support in preterm infants with severe respiratory distress syndrome.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Sun, Huiqing Cheng, Rui Kang, Wengqing Xiong, Yun Zhou, Chongchen Zhang, Yinghui Wang, Xiaoyang Zhu, Changlian |
| Copyright Year | 2014 |
| Abstract | BACKGROUND Mechanical ventilation and surfactants are the standard treatment of preterm respiratory distress syndrome (RDS). The effects of the primary ventilation model on bronchopulmonary dysplasia (BPD) and long-term neurodevelopment outcomes are controversial. The purpose of this study was to compare the efficacy and safety of high-frequency oscillatory ventilation (HFOV) and synchronized intermittent mandatory ventilation plus pressure support ventilation (SIMV-PSV) in preterm infants with severe RDS. METHODS A total of 366 eligible preterm infants were randomly assigned to treatment with HFOV (n = 184) or SIMV-PSV (n = 182). Surfactant was applied if PaO2/FIO2 was < 200 mm Hg after 2 hours of ventilation. Primary outcomes were mortality or incidence of BPD. Secondary outcomes were duration of ventilation and hospitalization, surfactant requirements, pneumothorax, retinopathy of prematurity ≥ stage 2, and neurodevelopment at 18 months of corrected age. RESULTS Survival and complete outcome data were available for 288 infants at 18 months of corrected age. The incidence of death or BPD was significantly higher in the SIMV-PSV group (P = .001). The duration of mechanical ventilation and hospitalization was shorter and the incidence of surfactant requirement and retinopathy of prematurity was lower in the HFOV group (P < .001, P = .002, P = .04, respectively). Moderate or severe neurological disability was less frequent in the HFOV group than in the SIMV-PSV group at 18 months (P = .03). The combination of HFOV and surfactant dramatically reduced negative outcomes in preterm infants with severe RDS. CONCLUSIONS Initial ventilation with HFOV in preterm infants with severe RDS reduces the incidence of death and BPD, and improves long-term neurodevelopment outcomes. (ClinicalTrials.gov NCT01496508). |
| File Format | PDF HTM / HTML |
| DOI | 10.4187/respcare.02382 |
| PubMed reference number | 23764865 |
| Journal | Medline |
| Volume Number | 59 |
| Issue Number | 2 |
| Alternate Webpage(s) | http://rc.rcjournal.com/content/respcare/59/2/159.full.pdf |
| Alternate Webpage(s) | http://rc.rcjournal.com/content/59/2.toc.pdf |
| Alternate Webpage(s) | http://rc.rcjournal.com/content/respcare/59/2.toc.pdf |
| Alternate Webpage(s) | https://doi.org/10.4187/respcare.02382 |
| Journal | Respiratory care |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
