The effects of intravenous cilostazol and nimodipine on cerebral vasospasm after subarachnoid hemorrhage in an experimental rabbit model.

Content Provider	Semantic Scholar
Author	Bilginer, Burçak Onal, Mehmet Bulent Narin, Firat Soylemezoğlu, Figen Ziyal, Ibrahim M. Ozgen, Tunçalp
Copyright Year	2009
Abstract	AIM Our aim in this study was to investigate the efficacy of intravenous administration of cilostazol and compare these effects with intravenous usage of nimodipine in subarachnoid hemorrhage model. MATERIAL AND METHODS Twenty-five male New Zealand White rabbits were assigned randomly to 1 of 5 groups. Animals in group 1 (n=5) served as controls, group 2 (n=5) was the SAH-only group, group 3 (n=5) was treated with intravenous 10 mg/kg cilostazol, group 4 (n=5) was treated with 0.05 mg/kg intravenous nimodipine, and group 5 (n=5) served as the vehicle group and treated with a mixture of dimethyl sulfoxide and phosphate buffer solution. Basilar arteries were removed from the brain stems and analyzed. The vessels were measured using computer-assisted morphometry (SPOT for Windows Version 4.1). Statistical comparisons were performed using the Kruskall-Wallis and Mann-Whitney U tests. RESULTS Basilar artery wall thicknesses in group 3 and 4 were smaller than the group 2 and this was statistically significant at p < 0.05. The mean arterial cross-sectional areas in group 3 and 4 were higher than group 2 and this was also statistically significant at p < 0.05. CONCLUSION Our results demonstrate that intravenous administration of both cilostazol and nimodipine significantly attenuates cerebral vasospasm after SAH.
File Format	PDF HTM / HTML
PubMed reference number	19847758
Journal	Medline
Volume Number	19
Issue Number	4
Alternate Webpage(s)	http://www.turkishneurosurgery.org.tr/pdf/pdf_JTN_700.pdf
Journal	Turkish neurosurgery
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article