NDLI: Neurotrophic factor expression after CNS viral injury produces enhanced sensitivity to psychostimulants: potential mechanism for addiction vulnerability.

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Neurotrophic factor expression after CNS viral injury produces enhanced sensitivity to psychostimulants: potential mechanism for addiction vulnerability.

Content Provider	Semantic Scholar
Author	Solbrig, Marylou V. Koob, George F. Parsons, Loren Howell Kadota, Tomohito Horscroft, Nigel Briese, T. Lipkin, W. Ian
Copyright Year	2000
Abstract	Hypothesized risk factors for psychostimulant, amphetamine, and cocaine abuse include dopamine (DA) receptor polymorphisms, HIV infection, schizophrenia, drug-induced paranoias, and movement disorders; however, the molecular, cellular, and biochemical mechanisms that predispose to drug sensitivity or drive the development of addiction are incompletely understood. Using the Borna disease rat, an animal model of viral-induced encephalopathy wherein sensitivity to the locomotor and stereotypic behavioral effects of d-amphetamine and cocaine is enhanced (Solbrig et al., 1994, 1998), we identify a specific neurotrophin expression pattern triggered by striatal viral injury that increases tyrosine hydroxylase activity, an early step in DA synthesis, to produce a phenotype of enhanced amphetamine sensitivity. The reactive neurotrophin pattern provides a molecular framework for understanding how CNS viral injury, as well as other CNS adaptations producing similar growth factor activation profiles, may influence psychostimulant sensitivity.
Starting Page	RC104
Ending Page	RC104
Page Count	1
File Format	PDF HTM / HTML
Alternate Webpage(s)	http://academiccommons.columbia.edu/download/fedora_content/download/ac:130213/CONTENT/jneurosci.20.21.rc104.pdf
Alternate Webpage(s)	https://academiccommons.columbia.edu/download/fedora_content/download/ac:130213/CONTENT/jneurosci.20.21.rc104.pdf
Alternate Webpage(s)	http://www.jneurosci.org/content/jneuro/20/21/np.full.pdf
Alternate Webpage(s)	https://www.mailman.columbia.edu/sites/default/files/legacy/neurotrophicfactorexpressionaftercnsviralinjury.pdf
Alternate Webpage(s)	http://www.jneurosci.org/content/jneuro/20/21.cover.pdf
Alternate Webpage(s)	http://www.jneurosci.org/content/jneuro/20/21/RC104.full.pdf
PubMed reference number	11050146v1
Volume Number	20
Issue Number	21
Journal	The Journal of neuroscience : the official journal of the Society for Neuroscience
Language	English
Access Restriction	Open
Subject Keyword	Acclimatization Addictive Behavior Amphetamine Borna Disease Brain Diseases Cocaine Dextroamphetamine Dopamine Growth Factor Mixed Function Oxygenases Movement Disorders Paranoia Schizophrenia Substance Dependence Virus Diseases psychostimulant tyrosine 3-monooxygenase activity
Content Type	Text
Resource Type	Article

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