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Nitrite anion: the key intermediate in alkyl nitrates degradative mechanism.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Grossi, Loris |
| Copyright Year | 2008 |
| Abstract | Alkyl nitrates are metabolized in vitro to yield nitric oxide, and thiol groups have long been considered necessary cofactors. Here, we report evidence that no reaction between thiols and alkyl nitrates takes place in vitro, but stronger reducing agents, such as iron(II) derivatives, are necessary; alkoxy radicals and nitrite anions are the reaction intermediates. The latter, in slightly acidic conditions, can nitrosate thiols to the corresponding S-nitrosothiols, the real NO releasers. |
| File Format | PDF HTM / HTML |
| DOI | 10.1021/jm701390c |
| Alternate Webpage(s) | http://precedings.nature.com/documents/235/version/1/files/npre2007235-1.pdf |
| PubMed reference number | 18442229 |
| Alternate Webpage(s) | https://doi.org/10.1021/jm701390c |
| Journal | Medline |
| Volume Number | 51 |
| Issue Number | 11 |
| Journal | Journal of medicinal chemistry |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
