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BDNF serum concentrations show no relationship with diagnostic group or medication status in neurodegenerative disease.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Woolley, Joshua D. Strobl, Eric V. Shelly, Wendy B. Karydas, Anna M. Ketelle, R. N. Robin Wolkowitz, Owen M. Miller, Bruce L. Rankin, Katherine P. |
| Copyright Year | 2012 |
| Abstract | Brain-derived neurotrophic factor (BDNF) is a growth factor implicated in neuronal survival. Studies have reported altered BDNF serum concentrations in patients with Alzheimer's disease (AD). However, these studies have been inconsistent. Few studies have investigated BDNF concentrations across multiple neurodegenerative diseases, and no studies have investigated BDNF concentrations in patients with frontotemporal dementia. To examine BDNF concentrations in different neurodegenerative diseases, we measured serum concentrations of BDNF using enzyme-linked immunoassay in subjects with behavioral-variant frontotemporal dementia (bvFTD, n=20), semantic dementia (SemD, n=16), AD (n=34), and mild cognitive impairment (MCI, n=30), as well as healthy older subjects (HS, n=38). BDNF serum concentrations were compared across diagnoses and correlated with cognitive tests and patterns of brain atrophy using voxelbased morphometry. We found small negative correlations between BDNF serum concentrations and some of the cognitive tests assessing learning, information processing speed and cognitive control in complex situations, however, BDNF did not predict disease group membership despite adequate power. These findings suggest that BDNF serum concentration may not be a reliable diagnostic biomarker to distinguish among neurodegenerative diseases. |
| Starting Page | 48 |
| Ending Page | 54 |
| Page Count | 7 |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | http://woolleylab.ucsf.edu/sites/woolleylab.ucsf.edu/files/wysiwyg/BDNF%20serum%20concentrations%20show%20no%20relationship%20with%20diagnostic%20group%20or%20medication%20status%20in%20neurodegenerative%20disease.pdf |
| PubMed reference number | 21605064v1 |
| Volume Number | 9 |
| Issue Number | 7 |
| Journal | Current Alzheimer research |
| Language | English |
| Access Restriction | Open |
| Subject Keyword | Alzheimer's Disease Atrophic Biological Markers Cerebral atrophy Cognition Disorders Frontotemporal dementia Growth Factor Immunoassay method Morphometric analysis Neurodegenerative Disorders Patients Semantic Dementia |
| Content Type | Text |
| Resource Type | Article |
