Loading...
Please wait, while we are loading the content...
Similar Documents
Is tau a preload-independent measure of isovolumetric relaxation?
| Content Provider | Semantic Scholar |
|---|---|
| Author | Varma, Shalendra K. Owen, Robert M. Smucker, Mark L. Feldman, Marc D. |
| Copyright Year | 1989 |
| Abstract | Several studies have been performed in patients with a variety of myocardial diseases that have identified a prolongation of tau. However, it is not clear whether prolongation of tau represents abnormal myocardial physiology or the effect of excessive load associated with a particular disease process. Accordingly, we evaluate the effect on tau of an isolated decrease in preload induced by inferior vena cava occlusion before the appearance of reflex changes in six patients designated as normal by catheterization criteria. A computer-based digitization routine identified cardiac contractions in all patients early after inferior vena cava occlusion where left ventricular end-diastolic pressure decreased (18.3 +/- 6.3 to 9.3 +/- 5.8, p less than 0.05) while left ventricular systolic pressure (113.3 +/- 13.8 to 111.8 +/- 14.0, p = NS) and heart rate (66.0 +/- 10.0 to 65.9 +/- 10.3, p = NS) did not change. After this alteration in preload, no change in tau from baseline, as calculated by the logarithmic (TL), derivative (TD), or method of Mirsky (T1/2), was noted: TL, 47.4 +/- 6.5 to 44.6 +/- 7.6; TD, 39.3 +/- 8.1 to 39.8 +/- 8.4; T1/2, 33.0 +/- 4.0 to 31.8 +/- 4.6; all p = NS. The baseline pressure extrapolated from isovolumetric relaxation did not change in these preload beats compared with baseline (+4.26 +/- 6.20 to -0.80 +/- 4.87, p = NS). Subsequent beats were identified where left ventricular systolic pressure showed a numeric decrease compared with baseline (113.3 +/- 13.8 to 100.8 +/- 14.3, p = NS) despite no change in heart rate (66.0 +/- 10.0 to 66.8 +/- 10.5, p = NS).(ABSTRACT TRUNCATED AT 250 WORDS) |
| Starting Page | 1 |
| Ending Page | 4 |
| Page Count | 4 |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | http://circ.ahajournals.org/content/circulationaha/80/6/1757.full.pdf |
| Alternate Webpage(s) | http://circ.ahajournals.org/content/circulationaha/80/6/1757.full.pdf?download=true |
| Alternate Webpage(s) | http://circ.ahajournals.org/content/circulationaha/80/6/1757.full.pdf?ijkey=d3e15447bf2c555481c74b081cb60b04fcda3f9c |
| PubMed reference number | 2598435v1 |
| Volume Number | 80 |
| Issue Number | 6 |
| Journal | Circulation |
| Language | English |
| Access Restriction | Open |
| Subject Keyword | BaseLine dental cement Cardiomyopathies Diastole Diastolic blood pressure Dyskinesia, Drug-Induced Inferior vena cava structure Numbers Patients Premature ventricular contractions Reflex action Structure of vein of trunk Systolic Pressure physiological aspects uridine triacetate |
| Content Type | Text |
| Resource Type | Article |
