NDLI: Prognostic value of end-tidal carbon dioxide during exercise testing in heart failure.

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Prognostic value of end-tidal carbon dioxide during exercise testing in heart failure.

Content Provider	Semantic Scholar
Author	Arena, Ross Guazzi, Marco Myers, Jonathan
Copyright Year	2007
Abstract	BACKGROUND The partial pressure of end-tidal carbon dioxide production (P(ET)CO2) at ventilatory threshold (VT) has been shown to be strongly correlated with cardiac output during exercise in patients with heart failure (HF), but few data are available regarding its prognostic utility. AIMS The purpose of this study was to assess the ability of P(ET)CO2 to predict cardiac-related events in a group of subjects with HF. METHODS One hundred and thirty subjects diagnosed with compensated HF underwent cardiopulmonary exercise testing (CPX). Peak oxygen consumption (VO2), the minute ventilation-carbon dioxide production (VE/VCO2) slope and P(ET)CO2 were determined. RESULTS Receiver operating characteristic (ROC) curve analysis revealed that P(ET)CO2 at the ventilatory threshold (VT) was a significant predictor of cardiac-related events (ROC area=0.82, p<0.001). The optimal P(ET)CO2 at a VT threshold value for separating high (< or =) and low (>) risk groups was 36.1 mm Hg (77% sensitivity, 69% specificity). In a multivariate Cox regression analysis, P(ET)CO2 at VT added significant predictive value to the VE/VCO2 slope and peak VO2. CONCLUSION These results indicate that P(ET)CO2 during CPX is a significant predictor of cardiac-related events in patients with HF. Clinical assessment of this variable in patients with HF undergoing CPX may therefore be warranted.
Starting Page	28
Ending Page	28
Page Count	1
File Format	PDF HTM / HTML
Alternate Webpage(s)	http://cardiology.org/recentpapers/New%20PDFs%20HF%20CPX/Arena%20ETCO2%20and%20Prognosis%202007.pdf
PubMed reference number	16843545v1
Volume Number	117
Issue Number	1
Journal	International journal of cardiology
Language	English
Access Restriction	Open
Subject Keyword	Carbon Dioxide Cardiac Output Cardiopulmonary Exercise Test Exercise stress test Heart failure Mercury Oxygen consumption measurement Partial Pressure Patients Receiver Operating Characteristic Receiver Operator Characteristics Respiration Ventilatory Threshold
Content Type	Text
Resource Type	Article

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