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Characterization of strychnine-sensitive glycine receptors in acutely isolated adult rat basolateral amygdala neurons
| Content Provider | Semantic Scholar |
|---|---|
| Author | McCool, Brian A. Botting, Shaleen Kaye |
| Copyright Year | 2000 |
| Abstract | Large concentrations of the beta-amino acid, taurine, can be found in many forebrain areas such as the basolateral amygdala, a portion of the limbic forebrain intimately associated with the regulation of fear/anxiety-like behaviors. In addition to its cytoprotective and osmoregulatory roles, taurine may also serve as an agonist at GABA(A)- and strychnine-sensitive glycine receptors. In this latter context, the present study demonstrates that application of taurine to acutely isolated neurons from the basolateral amygdala of adult rats causes significant alterations in resting membrane current, as measured by whole-cell patch clamp electrophysiology. Using standard pharmacological approaches, we find that currents gated by concentrations of taurine |
| Starting Page | 341 |
| Ending Page | 351 |
| Page Count | 11 |
| File Format | PDF HTM / HTML |
| DOI | 10.1016/S0006-8993(00)02026-6 |
| Alternate Webpage(s) | https://api.elsevier.com/content/article/pii/S0006899300020266 |
| Alternate Webpage(s) | https://www.sciencedirect.com/science/article/pii/S0006899300020266?dgcid=api_sd_search-api-endpoint |
| Alternate Webpage(s) | http://www.wakehealth.edu/assets/0/76/83/85/96/1998/2728/2729/2759/245db1f0-a406-4986-871e-7670abb69b8b.pdf |
| Alternate Webpage(s) | https://www.wfubmc.edu/assets/0/76/83/85/96/1998/2728/2729/2759/245db1f0-a406-4986-871e-7670abb69b8b.pdf |
| PubMed reference number | 10719083 |
| Alternate Webpage(s) | https://doi.org/10.1016/S0006-8993%2800%2902026-6 |
| Journal | Medline |
| Volume Number | 859 |
| Journal | Brain Research |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
