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The role of cDC 1 s : CD 8 T cell priming through in vivo cross-presentation
| Content Provider | Semantic Scholar |
|---|---|
| Author | Murphy |
| Copyright Year | 2019 |
| Abstract | The cDC1 subset of classical dendritic cells is specialized for priming CD8 T cell responses through the process of cross-presentation. The molecular mechanisms of cross-presentation remain incompletely understood because of limited biochemical analysis of rare cDC1 cells, difficulty in their genetic manipulation, and reliance on systems based on monocytein vitro and bone-marrow-derived dendritic cells. This review will discuss cross-presentation from the perspective of studies with monocyteor bone-marrow-derived dendritic cells while highlighting the need for future work examining cDC1 cells. We then discuss the role of cDC1s as a cellular platform to combine antigen processing for class I and class II MHC presentation to allow the integration of “help” from CD4 T cells during priming of CD8 T cell responses. |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | https://f1000researchdata.s3.amazonaws.com/manuscripts/10773/2a7c97d9-5973-4674-8aa8-a92f4ddc7a3e_9997_-_kenneth_murphy.pdf?doi=10.12688/f1000research.9997.1&numberOfBrowsableCollections=17&numberOfBrowsableGateways=22&numberOfBrowsableInstitutionalCollections=4 |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |