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Myelodysplastic syndrome following therapy for brain tumor--two case reports.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Sugiyama, Kazuhiko Kurisu, Kaoru Arita, Kazunori Taniguchi, Eiji Okamura, Tatsunori Itoh, Yoko Yamasaki, Fumiyuki Kajiwara, Yoshinori Ueda, Hiroyuki Sakai, Akira |
| Copyright Year | 2002 |
| Abstract | A 3-month-old boy and a 29-year-old woman presented with myelodysplastic syndrome (MDS) following therapy for primary malignant brain tumor. Both received intensive alkylating agent doses for induction and maintenance chemotherapy combined with craniospinal or cranial radiation for medulloblastoma and anaplastic astrocytoma, respectively. They developed refractory anemia and pancytopenia. Approximately 9 years after the completion of induction chemoradiotherapy, chromosomal analysis of bone marrow cells resulted in the diagnosis of MDS. The boy died of leukemic evolution 15 months later, the woman died of hematopoietic failure 3 months later. The most common symptom of MDS is refractory anemia, either alone or as part of bi- or pancytopenia. Clonal proliferation with chromosomal analysis of bone marrow cells establishes the diagnosis of MDS. Patients with malignant brain tumors are at risk of the development of MDS as a late complication of chemotherapy based on high cumulative doses of alkylating agents. |
| Starting Page | 1935 |
| Ending Page | 1938 |
| Page Count | 4 |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | https://www.jstage.jst.go.jp/article/nmc/42/4/42_4_170/_pdf/-char/en |
| PubMed reference number | 12013670v1 |
| Volume Number | 42 |
| Issue Number | 4 |
| Journal | Neurologia medico-chirurgica |
| Language | English |
| Access Restriction | Open |
| Subject Keyword | Alkylating Agents Anemia Brain Neoplasms Cessation of life Chemoradiotherapy Childhood Cerebral Astrocytoma Liver Failure, Acute MYELODYSPLASTIC SYNDROME Malignant neoplasm of brain Medulloblastoma Pancytopenia Refractory anemias pediatric intracranial germ cell brain tumor recurrent childhood brain stem glioma |
| Content Type | Text |
| Resource Type | Article |
