NDLI: Glycogen synthase kinase-3 in insulin and Wnt signalling: a double-edged sword?

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Glycogen synthase kinase-3 in insulin and Wnt signalling: a double-edged sword?

Content Provider	Semantic Scholar
Author	Patel, Satish Doble, Bradley W. Woodgett, James R.
Copyright Year	2004
Abstract	Glycogen synthase kinase-3 is an unusual protein serine/threonine kinase that, unlike most of its 500-odd relatives in the genome, is active under resting conditions and is inactivated upon cell stimulation. The two mammalian isoforms, GSK-3alpha and beta, play largely overlapping roles and have been implicated in a variety of human pathologies, including Type II diabetes, Alzheimer's disease, bipolar disorder and cancer. Recently, the modes of regulation of this enzyme have been elucidated through a combination of structural and cell biological studies. A series of relatively selective small molecules have facilitated chemical manipulation of the enzyme in intact cells and tissues, and new roles for the protein kinase in embryonic stem cell differentiation and motility have emerged. Despite these advances, the therapeutic value of this enzyme as a drug target remains clouded by uncertainty over the potential of antagonists to promote tumorigenesis. This article describes the state of understanding of this intriguing enzyme, and weighs current evidence regarding whether there is a therapeutic window for amelioration of diseases in which it is implicated, in the absence of inducing new pathologies.
Starting Page	75
Ending Page	92
Page Count	18
File Format	PDF HTM / HTML
Alternate Webpage(s)	http://www.biochemsoctrans.org/content/ppbiost/32/5/803.full.pdf
PubMed reference number	15494020v1
Volume Number	32
Part	5
Journal	Biochemical Society transactions
Language	English
Access Restriction	Open
Subject Keyword	Alzheimer's Disease Bipolar Disorder Body tissue Carcinogenesis Cell Differentiation process Diabetes Mellitus, Insulin-Dependent Drug Delivery Systems Embryonic Stem Cells Glycogen (Starch) Synthase Glycogen Storage Disease Type III MARK2 gene Mammals Protein Isoforms Protein Kinases Protein-Serine-Threonine Kinases Rest Small Molecule Stem Cell Differentiation Threonine biological signaling glycogen synthase kinase 3 alpha therapeutic index
Content Type	Text
Resource Type	Article

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