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Equilibrative nucleoside transporter 1 (ENT1) regulates postischemic blood flow during acute kidney injury in mice.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Grenz, Almut Bauerle, Jessica D. Dalton, Julee H. Ridyard, Douglas Badulak, Alexander Tak, Eunyoung McNamee, Eóin N. Clambey, Eric T. Moldovan, Radu Reyes, Germán L. Vélez Klawitter, Jost Ambler, Kelly Magee, Kristann Christians, Uwe Brodsky, Kelley S. Ravid, Katya Choi, Doo-Sup Wen, Jiaming Lukashev, Dmitriy E. Blackburn, Michael R. Osswald, Hartmut Coe, Imogen R. Nürnberg, Bernd Haase, Volker H. Xia, Yang Sitkovsky, Michail Eltzschig, Holger K. |
| Copyright Year | 2017 |
| Abstract | A complex biologic network regulates kidney perfusion under physiologic conditions. This system is profoundly perturbed following renal ischemia, a leading cause of acute kidney injury (AKI) — a life-threatening condition that frequently complicates the care of hospitalized patients. Therapeutic approaches to prevent and treat AKI are extremely limited. Better understanding of the molecular pathways promoting postischemic reflow could provide new candidate targets for AKI therapeutics. Due to its role in adapting tissues to hypoxia, we hypothesized that extracellular adenosine has a regulatory function in the postischemic control of renal perfusion. Consistent with the notion that equilibrative nucleoside transporters (ENTs) terminate adenosine signaling, we observed that pharmacologic ENT inhibition in mice elevated renal adenosine levels and dampened AKI. Deletion of the ENTs resulted in selective protection in Ent1–/– mice. Comprehensive examination of adenosine receptor–knockout mice exposed to AKI demonstrated that renal protection by ENT inhibitors involves the A2B adenosine receptor. Indeed, crosstalk between renal Ent1 and Adora2b expressed on vascular endothelia [...] Research Article Nephrology |
| Starting Page | 2438 |
| Ending Page | 2438 |
| Page Count | 1 |
| File Format | PDF HTM / HTML |
| DOI | 10.1172/JCI94890 |
| PubMed reference number | 28569735 |
| Journal | Medline |
| Volume Number | 127 |
| Issue Number | 6 |
| Alternate Webpage(s) | https://dm5migu4zj3pb.cloudfront.net/manuscripts/60000/60214/cache/60214.2-20170522151155-covered-253bed37ca4c1ab43d105aefdf7b5536.pdf |
| Alternate Webpage(s) | https://doi.org/10.1172/JCI94890 |
| Journal | The Journal of clinical investigation |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
