NDLI: Little Things that Count in Transcriptional Regulation

Content Provider	Semantic Scholar
Author	Natoli, Gioacchino
Copyright Year	2004
Abstract	Although the NF-kappaB transcription factor tolerates significant sequence variations in its DNA binding site, NF-kappaB sites show remarkable evolutionary stability. In this issue of Cell, demonstrate that a single nucleotide change in an NF-kappaB binding site changes the dependence of the promoter on a specific coactivator without affecting NF-kappaB binding. These data suggest that binding sites may impart a specific configuration to bound transcription factors.
Starting Page	406
Ending Page	408
Page Count	3
File Format	PDF HTM / HTML
DOI	10.1016/j.cell.2004.08.003
PubMed reference number	15315753
Journal	Medline
Volume Number	118
Alternate Webpage(s)	https://api.elsevier.com/content/article/pii/S0092867404007470
Alternate Webpage(s)	https://www.sciencedirect.com/science/article/pii/S0092867404007470
Alternate Webpage(s)	https://doi.org/10.1016/j.cell.2004.08.003
Journal	Cell
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article

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Little Things that Count in Transcriptional Regulation