NDLI: Hepatoprotective Effect of Sarvakalp Kwath Against Carbon Tetrachloride Induced Hepatic Injury in Albino Rats

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Hepatoprotective Effect of Sarvakalp Kwath Against Carbon Tetrachloride Induced Hepatic Injury in Albino Rats

Content Provider	Semantic Scholar
Author	Yadav, Akash Kumar, Suresh
Copyright Year	2015
Abstract	Modern medicine, even in the modern era, lacks effective medications in its armamentarium which could be useful to treat or prevent hepatic ailments. However, Indian Ayurvedic system claims to have many indigenous plants and herbal preparations which provide therapeutic benefit in the treatment of liver diseases. One of such herbal preparations claiming to be of benefit in liver diseases is Sarvakalp Kwath by Divya Pharmacy, Haridwar. This study was undertaken to explore the hepatoprotective effects of Sarvakalp Kwath in animal model using albino rats. The animals were administered aqueous extract of the preparation in the dose of 120 mg/kg for seven days followed by carbon tetrachloride (CCl4) challenge. Animals were then sacrificed. Hepatic damage and protection from the damage was assessed by biochemical parameters viz. alanine transaminase, alkaline phosphatase, total bilirubin and albumin as well as histological studies. It was observed that aqueous extract of Sarvakalp Kwath offered significant hepatoprotection as reflected by improvement in all biochemical and histological parameters as compared to saline controls. In conclusion, Sarvakalp Kwath offers significant hepatoprotection as is observed in this study. Further studies are warranted to establish its therapeutic efficacy in humans.
File Format	PDF HTM / HTML
Alternate Webpage(s)	http://www.biomedpharmajournal.org/dnload/A-Yadav-and-S-Kumar-/BPJV07I02P659-663.pdf
Language	English
Access Restriction	Open
Subject Keyword	Alanine Transaminase Alkaline Phosphatase Bilirubin Carbon Tetrachloride Chemical and Drug Induced Liver Injury Illness (finding) Liver diseases Plant Preparations Punarnavadi-kwath SalineOS Transaminases Viz: The Computer Game
Content Type	Text
Resource Type	Article

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