NDLI: Oxidative damage in substantia nigra and striatum of rats chronically exposed to ozone

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Oxidative damage in substantia nigra and striatum of rats chronically exposed to ozone

Content Provider	Semantic Scholar
Author	Pereyra-Muñoz, Naira Rugerio-Vargas, Concepción Angoa-Pérez, Mariana Borgonio-Pérez, Gabino Rivas-Arancibia, Selva
Copyright Year	2006
Abstract	The purpose of this work was to study if chronic low-dose ozone exposure could per se induce oxidative damage to neurons of striatum and substantia nigra. Thirty male Wistar rats were divided into three groups--Group 1: exposed to an air stream free of ozone; Group 2: exposed for 15 days to ozone; Group 3: exposed for 30 days to ozone. Ozone exposure was carried out daily for 4 h at a 0.25 ppm dose. Each group was then tested for (1) motor activity, (2) quantification of lipid peroxidation levels, (3) Klüver-Barrera staining, and (4) immunohistochemistry for tyrosine hydroxylase (TH), dopamine and adenosine 3',5'-monophosphate-regulated phosphoprotein of 32 kD (DARPP-32), inducible nitric oxide synthase (iNOS), and superoxide dismutase (SOD), to study neuronal alterations in striatum and substantia nigra. Results indicate that ozone exposure causes a significant decrease in motor activity. Ozone produced lipid peroxidation, morphological alterations, loss of fibers and cell death of the dopaminergic neurons. The DARPP-32, iNOS and SOD expression increased with repetitive ozone exposure. These alterations suggest that ozone causes oxidative stress which induces oxidative damage to substantia nigra and striatum of the rat.
Starting Page	114
Ending Page	123
Page Count	10
File Format	PDF HTM / HTML
DOI	10.1016/j.jchemneu.2005.09.006
PubMed reference number	16236481
Journal	Medline
Volume Number	31
Alternate Webpage(s)	https://api.elsevier.com/content/article/pii/S0891061805001122
Alternate Webpage(s)	https://www.sciencedirect.com/science/article/pii/S0891061805001122?dgcid=api_sd_search-api-endpoint
Alternate Webpage(s)	https://doi.org/10.1016/j.jchemneu.2005.09.006
Journal	Journal of Chemical Neuroanatomy
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article

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