NDLI: AMP-activated Protein Kinase Suppresses Connexin43 in Bladder Smooth Muscle Cells and Ameliorates Voiding Dysfunction in Cyclophosphamide-induced Mouse Cystitis

Content Provider	Semantic Scholar
Author	Zhang, Xiling Yao, Jian Ihara, Tatsuya Sawada, Norifumi Mitsui, Takahiko Takeda, Masayuki
Copyright Year	2015
Abstract	Hypothesis / aims of study Lower urinary tract symptoms are common and impair Quality of life, especially in elderly population. Accumulating evidence indicate that many types of lower urinary tract dysfunction are closely related to local oxidation, inflammation, as well as overactivity of several channels, including connexin 43 (Cx43) channels (1)(2). Given that AMPK, a key regulator of cellular energy homeostasis, has anti-oxidative, anti-inflammatory, and channel-inhibiting properties, we speculated that AMPK might be exploited for treatment of refractory overactive bladder. The aim of this study was to test this hypothesis.
File Format	PDF HTM / HTML
Alternate Webpage(s)	https://www.ics.org/Abstracts/Publish/241/000466.pdf
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article

Central Library (ISO-9001:2015 Certified)
Indian Institute of Technology Kharagpur
Kharagpur, West Bengal, India | PIN - 721302

See location in the Map
03222 282435
Mail: support@ndl.gov.in

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in