NDLI: Enantioselective synthesis of benzoindolizidine derivatives using chiral phase-transfer catalytic intramolecular domino aza-Michael addition/alkylation.

Content Provider	Semantic Scholar
Author	Guo, Jiajia Yu, Shouyun
Copyright Year	2015
Abstract	An efficient and enantioselective strategy to synthesize benzoindolizidines from α,β-unsaturated amino ketones via domino intramolecular aza-Michael addition/alkylation was developed. These reactions were enabled by cinchona alkaloid-derived quaternary ammonium salts as the phase-transfer catalyst. A variety of benzoindolizidines were prepared in good yields (up to 93%) and enantioselectivities (up to 92.8:7.2 er).
File Format	PDF HTM / HTML
DOI	10.1039/c4ob02227k
PubMed reference number	25428596
Journal	Medline
Volume Number	13
Issue Number	4
Alternate Webpage(s)	http://www.rsc.org/suppdata/ob/c4/c4ob02227k/c4ob02227k1.pdf
Alternate Webpage(s)	https://doi.org/10.1039/c4ob02227k
Journal	Organic & biomolecular chemistry
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article

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