NDLI: Correlation between Midkine Protein Overexpression in Hepatocellular Carcinoma with the Presence of Tumor Cells in Circulating Blood

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Correlation between Midkine Protein Overexpression in Hepatocellular Carcinoma with the Presence of Tumor Cells in Circulating Blood

Content Provider	Semantic Scholar
Author	Yin, Zhengfeng Kang, Xiaoyan Luo, Xiangji Qian, Haihua Wu, Zongdi Wu, Meng-Chao
Copyright Year	2007
Abstract	Chinese Journal of Clinical Oncolgy Email: COCR@eyou.com Tel(Fax): 86-22-2352-2919 OBJECTIVE To ~nvest~gate m~dkine (MK) prote~n expression rn human hepatocellular carcinoma (HCC) and rts relation to dissemination of cancer cells in blood. METHODS Circulating tumor cells were detected in preoperative blood samples using reverse transcription polymerase chain reaction (RT-PCR) for alpha-fetoprotein (AFP) mRNA. Midkine expression was immunohistochemically examined in surgically resected HCC tissues. RESULTS Forty-one HCC patients with positive serum AFP were studied. Positive AFP mRNA expression was shown in 18 preoperative blood samples (43.9%) and midkine overexpression was detected in 29 excised tumors (70.7%). Among the 29 patients, 18 (62.1%) showed positive AFP mRNA in their preoperative blood samples. In contrast, the positive AFP mRNA expression was only observed in 3 out of 12 patients (25.0%) without aberrant midkine expression. Statistical analysis showed that abnormal midkine expression in the tumors was a variant significantly associat&~ with the presence of tumor cells in the blood circulation (P<0.05). CONCLUSION In human hepatocellular carcinoma, midkine overexpression is correlated with a haematogenuous spread of the primary tumor cells, and ~t may be a marker for tumor metastatic potential.
File Format	PDF HTM / HTML
Alternate Webpage(s)	http://www.cancerbiomed.org/index.php/cocr/article/download/502/473
Language	English
Access Restriction	Open
Subject Keyword	Abnormal end Adrenergic alpha-Agonists Blood specimen Body tissue DEC Alpha Email Fetal Proteins Human-centered computing Liver carcinoma MDK protein, human Neoplasms Operative Surgical Procedures Patients Reverse Transcriptase Polymerase Chain Reaction Reverse Transcription Transcription (software) primary tumor
Content Type	Text
Resource Type	Article

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