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Vaginal micronized progesterone versus intramuscular progesterone for luteal support in women undergoing in vitro fertilization-embryo transfer.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Mitwally, Mohamed F. M. Diamond, Michael P. Abuzeid, Mostafa |
| Copyright Year | 2010 |
| Abstract | OBJECTIVE To study the outcome of IVF-ET in women who used vaginal P (vaginal P(4)) versus those who used P in oil via IM injection (IM-P(4)) for luteal support. DESIGN Retrospective cohort. SETTING Tertiary referral infertility center. PATIENT(S) A cohort of 544 women. INTERVENTION(S) In 145 women, vaginal P(4) was used, while in 399 women, IM-P(4) was used for luteal support. MAIN OUTCOME MEASURE(S) The primary outcome was ongoing pregnancy rate. Secondary outcomes included other IVF-ET outcomes: rates of clinical pregnancy and pregnancy loss (chemical and miscarriage) and serum P levels during the luteal phase and early pregnancy. RESULT(S) Women who used vaginal P(4) for luteal support had ongoing pregnancy rates (odds ratio [OR], 1.0675; 95% confidence interval [CI], 0.7587-1.5020) and rates of total pregnancy loss (OR, 1.0775; 95% CI, 0.7383-1.5727) that were not statistically different from those who used IM-P(4). During the luteal phase, women who used vaginal P(4) had mean serum P levels that were not statistically different from those who used IM-P(4). However, during early pregnancy, mean P levels in pregnant women who used vaginal P(4) were statistically significantly higher. CONCLUSION(S) In women undergoing IVF-ET according to the GnRH agonist long protocol, luteal support with vaginal P(4) was associated with treatment outcomes that were no different from those associated with IM-P(4) luteal support. |
| File Format | PDF HTM / HTML |
| DOI | 10.1016/j.fertnstert.2009.02.047 |
| PubMed reference number | 19362305 |
| Journal | Medline |
| Volume Number | 93 |
| Issue Number | 2 |
| Alternate Webpage(s) | http://www.medirequests.com/pdfs/Mitwally_MF_et_al_2010.pdf |
| Alternate Webpage(s) | https://doi.org/10.1016/j.fertnstert.2009.02.047 |
| Journal | Fertility and sterility |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
