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Regulation by aromatic amino acids of the biosynthesis of candicidin by Streptomyces griseus.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Gil, José Luis Adán Liras, Paloma Naharro, Germán |
| Copyright Year | 1980 |
| Abstract | The biosynthesis by Streptomyces griseus of candicidin, an aromatic polyene macrolide antibiotic, was inhibited by L-tryptophan, L-phenylalanine and, to a lesser degree, by L-tyrosine. A mixture of the three aromatic amino acids inhibited candicidin biosynthesis to a greater extent than did each amino acid separately. L-Tryptophan strongly inhibited the incorporation of the labelled precursors propionate or 4-aminobenzoic acid into candicidin. Incorporation of propionate into candicidin was 50% inhibited by 2.5 mM-tryptophan. Inhibition by tryptophan did not require protein synthesis as the same effect was observed in cells in which protein synthesis was prevented by chloramphenicol. The inhibitory effect of L-tryptophan was partially reversed by exogenous 4-aminobenzoic acid suggesting that this effect is exerted at the level of 4-aminobenzoic acid synthase. |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | http://www.microbiologyresearch.org/docserver/fulltext/micro/118/1/mic-118-1-189.pdf?accname=guest&checksum=E64A0B7111ABEDA52D72CD1F4C305FE0&expires=1541459714&id=id |
| Alternate Webpage(s) | http://www.microbiologyresearch.org/docserver/fulltext/micro/118/1/mic-118-1-189.pdf?accname=guest&checksum=C1996E8BA0DFA5E6C959895BC7F12A8B&expires=1540581380&id=id |
| PubMed reference number | 6775046v1 |
| Volume Number | 118 |
| Issue Number | 1 |
| Journal | Journal of general microbiology |
| Language | English |
| Access Restriction | Open |
| Subject Keyword | 4-Aminobenzoic Acid AROMATICS Amino Acid Metabolism, Inborn Errors Anabolism Aromatic Amino Acids Aromatic-L-Amino-Acid Decarboxylases Chloramphenicol Macrolide Antibiotics Macrolides Phenylalanine Polyenes Propionates Streptomyces griseus Tryptophan Transaminase Tyrosine candicidin biosynthetic process physical hard work |
| Content Type | Text |
| Resource Type | Article |
