Pathogenesis of pulmonary emphysema - cellular and molecular events.

Content Provider	Semantic Scholar
Author	Petta, Antonio Di
Copyright Year	2010
Abstract	Pulmonary emphysema is a chronic obstructive disease, resulting from important alterations in the whole distal structure of terminal bronchioles, either by enlargement of air spaces or by destruction of the alveolar wall, leading to loss of respiratory surface, decreased elastic recoil and lung hyperinflation. For many years, the hypothesis of protease-antiprotease unbalance prevailed as the central theme in the pathogenesis of pulmonary emphysema. According to this hypothesis, the release of active proteolytic enzymes, produced mainly by neutrophils and macrophages, degrades the extracellular matrix, affecting the integrity of its components, especially collagen and elastic fibers. However, new concepts involving cellular and molecular events were proposed, including oxidative stress, cell apoptosis, cellular senescence and failed lung tissue repair. The aim of this review paper was to evaluate the cellular and molecular mechanisms seen in the pathogenesis of pulmonary emphysema.
Starting Page	142
Ending Page	144
Page Count	3
File Format	PDF HTM / HTML
Alternate Webpage(s)	http://www.scielo.br/pdf/eins/v8n2/pt_1679-4508-eins-8-2-0248.pdf
Alternate Webpage(s)	http://apps.einstein.br/revista/arquivos/PDF/1480-Einstein_v8n2_p248-51.pdf
PubMed reference number	26760013v1
Alternate Webpage(s)	https://doi.org/10.1590/S1679-45082010RB1480
DOI	10.1590/S1679-45082010RB1480
Journal	Einstein
Volume Number	8
Issue Number	2
Language	English
Access Restriction	Open
Subject Keyword	Alveolar wall Apoptosis Bronchioles Cell Aging Chronic Obstructive Airway Disease Elastic Fibers Extracellular Matrix Hypertrophy Lung hyperinflation Oxidative Stress Protease Inhibitors Pulmonary Emphysema Structure of parenchyma of lung Wound Healing
Content Type	Text
Resource Type	Article