P224 Effect of the anodal transcranial direct current stimulation over the cerebellum on the motor cortex excitability

Content Provider	Semantic Scholar
Author	Cengiz, Bülent Ateş, Mehlika Panpalli Alaydin, Halil Can
Copyright Year	2017
Abstract	Introduction The aim of this study was to elucidate effect of the cerebellum on the motor cortex excitability and connectivity. We used cerebellar direct current stimulation (ctDCS) to modulate cerebellar excitability and hypothesized that anodal ctDCS would increase cerebellar excitability that will be cause to decrease motor cortical excitability via suppression of the dentato-thalamo-cortcal activity. Method Sixteen healthy adults participated to study. Motor cortex was stimulated with figure-of-eight- shaped coil of 9 cm diameter connected to two Magstim 200 stimulator linked with a Bistim module. Data acquisition and magnetic stimulus output were controlled by QTRAC software. Anodal stimulation was given for 20 min at 1 mA intensity. Investigated motor cortical excitability parameters were; resting motor threshold: (RMT), short interval intracortical inhibition (SICI), short interval intracortical facilitation (SICF) and intracortical facilitation (ICF). Results Factor analysis of SICI resulted in one factor with an eugenvealue over 1 which explained 86% of variance. SICI factors significantly decreased after anodal ctDCS ( p = 0.01) while there were no changes after sham ctDCS ( p = 0.96). Two factor with an eigenvalue over 1 were extracted from SICF factor analysis (SICF 2.4−4.4 and SICF 1.2−1.6. ). SICF 2.4−4.4 significantly decreased after anodalctDCS ( p = 0.01). There were no significant anodal ctDCS effect on RMT, ICF and I-O curve ( p > 0.05 ). Conclusion The cerebellum modulates both inhibitory and facilitator activities in the motor cortex. Significance Anodal ctDCS has dual effect on the motor cortex excitability. We hypothesized that this dual effect may be depends on its polarizing effect of both afferent facilitator, end efferent inhibitory systems.
File Format	PDF HTM / HTML
DOI	10.1016/j.clinph.2017.07.232
Volume Number	128
Alternate Webpage(s)	https://api.elsevier.com/content/article/pii/S1388245717307198
Alternate Webpage(s)	https://www.sciencedirect.com/science/article/pii/S1388245717307198?dgcid=api_sd_search-api-endpoint
Alternate Webpage(s)	https://doi.org/10.1016/j.clinph.2017.07.232
Journal	Clinical Neurophysiology
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article